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1. WO2013007765 - FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES

Publication Number WO/2013/007765
Publication Date 17.01.2013
International Application No. PCT/EP2012/063621
International Filing Date 12.07.2012
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07D 471/04 (2006.01)
A61K 31/437 (2006.01)
A61P 37/00 (2006.01)
CPC
C07D 471/04
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
  • BERGERON, Philippe [CA/US]; US (UsOnly)
  • BODIL VAN NIEL, Monique [NL/GB]; GB (UsOnly)
  • DRAGOVICH, Peter [US/US]; US (UsOnly)
  • HURLEY, Christopher [GB/GB]; GB (UsOnly)
  • KULAGOWSKI, Janusz [GB/GB]; GB (UsOnly)
  • LABADIE, Sharada [US/US]; US (UsOnly)
  • MCLEAN, Neville James [GB/GB]; GB (UsOnly)
  • MENDONCA, Rohan [US/US]; US (UsOnly)
  • PULK, Rebecca [US/US]; US (UsOnly)
  • ZAK, Mark [US/US]; US (UsOnly)
Inventors
  • BERGERON, Philippe; US
  • BODIL VAN NIEL, Monique; GB
  • DRAGOVICH, Peter; US
  • HURLEY, Christopher; GB
  • KULAGOWSKI, Janusz; GB
  • LABADIE, Sharada; US
  • MCLEAN, Neville James; GB
  • MENDONCA, Rohan; US
  • PULK, Rebecca; US
  • ZAK, Mark; US
Agents
  • SCHIRLIN, Julien; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data
61/507,56113.07.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES
(FR) COMPOSÉS TRICYCLIQUES FUSIONNÉS UTILISÉS EN TANT QU'INHIBITEURS DES JANUS KINASES
Abstract
(EN)
The invention provides novel compounds of formula (I) having the general formula (I) wherein R1, V, W, X, Y and Z are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
(FR)
L'invention concerne des nouveaux composés représentés par la formule générale (I) dans laquelle R1, V, W, X, Y et Z sont comme représentés dans la description. Par voie de conséquence, les composés peuvent être inclus dans des nouvelles compostions de qualité pharmaceutique et utilisés pour le traitement de troubles immunologiques ou hyperprolifératifs.
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