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1. WO2013007765 - FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES

Publication Number WO/2013/007765
Publication Date 17.01.2013
International Application No. PCT/EP2012/063621
International Filing Date 12.07.2012
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
  • BERGERON, Philippe [CA]/[US] (UsOnly)
  • BODIL VAN NIEL, Monique [NL]/[GB] (UsOnly)
  • DRAGOVICH, Peter [US]/[US] (UsOnly)
  • HURLEY, Christopher [GB]/[GB] (UsOnly)
  • KULAGOWSKI, Janusz [GB]/[GB] (UsOnly)
  • LABADIE, Sharada [US]/[US] (UsOnly)
  • MCLEAN, Neville James [GB]/[GB] (UsOnly)
  • MENDONCA, Rohan [US]/[US] (UsOnly)
  • PULK, Rebecca [US]/[US] (UsOnly)
  • ZAK, Mark [US]/[US] (UsOnly)
Inventors
  • BERGERON, Philippe
  • BODIL VAN NIEL, Monique
  • DRAGOVICH, Peter
  • HURLEY, Christopher
  • KULAGOWSKI, Janusz
  • LABADIE, Sharada
  • MCLEAN, Neville James
  • MENDONCA, Rohan
  • PULK, Rebecca
  • ZAK, Mark
Agents
  • SCHIRLIN, Julien
Priority Data
61/507,56113.07.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES
(FR) COMPOSÉS TRICYCLIQUES FUSIONNÉS UTILISÉS EN TANT QU'INHIBITEURS DES JANUS KINASES
Abstract
(EN) The invention provides novel compounds of formula (I) having the general formula (I) wherein R1, V, W, X, Y and Z are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
(FR) L'invention concerne des nouveaux composés représentés par la formule générale (I) dans laquelle R1, V, W, X, Y et Z sont comme représentés dans la description. Par voie de conséquence, les composés peuvent être inclus dans des nouvelles compostions de qualité pharmaceutique et utilisés pour le traitement de troubles immunologiques ou hyperprolifératifs.
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