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1. WO2013004740 - ANTICONVULSANT ACTIVITY OF TURMERIC OIL AND BISABOLENE SESQUITERPENOIDS

Publication Number WO/2013/004740
Publication Date 10.01.2013
International Application No. PCT/EP2012/063027
International Filing Date 04.07.2012
IPC
A61K 31/121 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
121acyclic
A61K 36/9066 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
906Zingiberaceae (Ginger family)
9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
A61P 25/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
CPC
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/121
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
121acyclic
A61K 36/9066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
906Zingiberaceae (Ginger family)
9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • KATHOLIEKE UNIVERSITEIT LEUVEN [BE]/[BE] (AllExceptUS)
  • UNIVERSIDAD DE CUENCA (AllExceptUS)
  • DE WITTE, Peter, A. M. [BE]/[BE] (UsOnly)
  • ESGUERRA, Camila, V. [US]/[BE] (UsOnly)
  • CRAWFORD, Alexander D. [DE]/[BE] (UsOnly)
  • ORELLANA PAUCAR, Adriana Monserrath [EC]/[EC] (UsOnly)
Inventors
  • DE WITTE, Peter, A. M.
  • ESGUERRA, Camila, V.
  • CRAWFORD, Alexander D.
  • ORELLANA PAUCAR, Adriana Monserrath
Agents
  • LAENEN, Bart
Priority Data
1111319.804.07.2011GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTICONVULSANT ACTIVITY OF TURMERIC OIL AND BISABOLENE SESQUITERPENOIDS
(FR) ACTIVITÉ ANTI-CONVULSION D'UNE HUILE DE CURCUMA ET DE BISABOLÈNE SESQUITERPÉNOÏDES
Abstract
(EN) The present invention relates to the anticonvulsant activity of turmeric oil and its volatile bisabolene sesquiterpenoids ar- turmerone, α-turmerone, β-turmerone (curlone) and α- atlantone, as an anticonvulsant agent for the treatment of epilepsy and/or as therapeutic agents for the treatment of disorders of the central nervous system, including tremor, pain, mood disorders (including depression, bipolar disorder, attention deficit-hyperactivity disorder, and schizophrenia), and neurodegenerative diseases.
(FR) La présente invention concerne l'activité anti-convulsion d'une huile de curcuma et de ses bisabolène ses quiterpénoïdes volatils ar-turmérone, α-turmérone, β-turmérone (curlone) et α-atlantone, en tant qu'agent anti-convulsion pour le traitement de l'épilepsie et/ou agents thérapeutiques pour le traitement de troubles du système nerveux central, comprenant des tremblements, la douleur, les troubles de l'humeur (comprenant la dépression, le trouble bipolaire, le trouble d'hyperactivité avec déficit de l'attention et la schizophrénie) et des maladies neurodégénératives.
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