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1. WO2013001507 - TREATMENT PLANNING BASED ON POLYPEPTIDE RADIOTOXICITY SERUM MARKERS

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Publication Number WO/2013/001507
Publication Date 03.01.2013
International Application No. PCT/IB2012/053323
International Filing Date 29.06.2012
IPC
A61N 5/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
G01N 33/574 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61N 5/1038
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
103Treatment planning systems
1038taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy
A61N 5/1039
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
103Treatment planning systems
1039using functional images, e.g. PET or MRI
G01N 2800/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
50Determining the risk of developing a disease
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 2800/60
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
60Complex ways of combining multiple protein biomarkers for diagnosis
G01N 33/57434
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57434of prostate
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL] (AllExceptUS)
  • BITTER, Katrin [DE]/[NL] (UsOnly)
  • RIBBING, Carolina [SE]/[DE] (UsOnly)
Inventors
  • BITTER, Katrin
  • RIBBING, Carolina
Agents
  • VAN VELZEN, Maaike
Priority Data
61/502,96030.06.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT PLANNING BASED ON POLYPEPTIDE RADIOTOXICITY SERUM MARKERS
(FR) SCHÉMA THÉRAPEUTIQUE REPOSANT SUR DES MARQUEURS SÉRIQUES DE RADIOTOXICITÉ POLYPEPTIDIQUES
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Abstract
(EN) A method includes at least one of creating or adapting a treatment plan for a patient based on a set of serum polypeptides of the patient that are indicative of a radiotoxicity of the patient at least one of before or after at least one of a plurality of radiotherapy treatments of the treatment plan, wherein the radiotoxicity is induced by radiation exposure from the radiotherapy treatment. A system includes a treatment planning device (108) that facilitates at least one of creating or adapting a treatment plan for a patient based on amounts or concentrations of a set of serum polypeptides of the patient that indicate a high risk of or an early radiotoxicity of the patient to radiation from radiotherapy.
(FR) La présente invention concerne un procédé comprenant la création ou l'adaptation d'un schéma thérapeutique pour un patient en fonction d'un ensemble de polypeptides sériques du patient qui sont des marqueurs d'une radiotoxicité chez le patient, avant et/ou après au moins l'un des traitements d'une pluralité de traitement de radiothérapie, la radiotoxicité étant induite par l'exposition à un rayonnement lors d'un traitement de radiothérapie. Un système comprend un dispositif d'établissement de schéma thérapeutique (108) qui facilite la création et/ou l'adaptation d'un schéma thérapeutique pour un patient en fonction de quantités ou de concentrations d'un ensemble de polypeptides sériques du patient qui indiquent un risque élevé ou une radiotoxicité précoce chez le patient exposé au rayonnement au cours d'une radiothérapie.
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