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1. WO2013001451 - VECTOR FOR THE RELEASE OF AN ACTIVE AGENT WHICH IS PHOTOCLEAVABLE BY IRRADIATION IN THE VISIBLE

Publication Number WO/2013/001451
Publication Date 03.01.2013
International Application No. PCT/IB2012/053220
International Filing Date 26.06.2012
IPC
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
B82Y 5/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82Y 15/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
15Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
CPC
A61K 41/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
008Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
A61K 47/6923
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6921the form being a particulate, a powder, an adsorbate, a bead or a sphere
6923the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA [IT]/[IT] (AllExceptUS)
  • SCUOLA NORMALE SUPERIORE DI PISA [IT]/[IT] (AllExceptUS)
  • CONSIGLIO NAZIONALE DELLE RICERCHE [IT]/[IT] (AllExceptUS)
  • VOLIANI, Valerio [IT]/[IT] (UsOnly)
  • LUIN, Stefano [IT]/[IT] (UsOnly)
  • NIFOSI, Riccardo [IT]/[IT] (UsOnly)
  • RICCI, Fernanda [IT]/[IT] (UsOnly)
  • SIGNORE, Giovanni [IT]/[IT] (UsOnly)
  • BELTRAM, Fabio [IT]/[IT] (UsOnly)
Inventors
  • VOLIANI, Valerio
  • LUIN, Stefano
  • NIFOSI, Riccardo
  • RICCI, Fernanda
  • SIGNORE, Giovanni
  • BELTRAM, Fabio
Agents
  • RAMBELLI, Paolo
Priority Data
TO2011A00056127.06.2011IT
Publication Language English (EN)
Filing Language Italian (IT)
Designated States
Title
(EN) VECTOR FOR THE RELEASE OF AN ACTIVE AGENT WHICH IS PHOTOCLEAVABLE BY IRRADIATION IN THE VISIBLE
(FR) VECTEUR POUR LA LIBÉRATION D'UN COMPOSANT ACTIF QUI EST PHOTOCLIVABLE PAR IRRADIATION DANS LE VISIBLE
Abstract
(EN)
A vector for the spatially and temporally controlled release of an active agent comprising nanoparticles of gold coated with a surfactant and an active agent bound to the said surfactant by means of a photocleavable bond, the said vector being capable of releasing the active agent when exposed to light radiation of wavelength greater than 400 nm included in the region of the visible or the region of the near infrared (NIR) through a multiple photon effect. In particular a vector in which the group having a photolabile bond is 1,2,3-triazole, which can for example be obtained by a click chemistry reaction between gold particles on the surface of which peptide molecules having a free carboxyl terminal group and an alkyne side group are chemiadsorbed and an azide of the active agent is described.
(FR)
L'invention concerne un vecteur pour la libération spatialement et temporairement contrôlée d'un composant actif comprenant des nanoparticules d'or revêtues d'un agent tensioactif et un composant actif lié audit agent tensioactif au moyen d'une liaison photoclivable, ledit vecteur étant apte à libérer le composant actif lorsqu'il est exposé à un rayonnement lumineux de longueur d'onde supérieure à 400 nm inclus dans la région du visible ou dans la région du proche infrarouge (NIR) par un effet à photons multiples. L'invention concerne, en particulier, un vecteur dans lequel le groupe ayant une liaison photolabile est 1,2,3-triazole, qui peut par exemple être obtenu par une réaction de chimie clic entre des particules d'or sur la surface desquelles des molécules peptides ayant un groupe terminal carboxyle libre et un groupe de côté alcyne sont chimiadsorbés et un azide du composant actif.
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