Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2012178036) INHIBITORS OF RTT109 AS ANTI-FUNGAL AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/178036 International Application No.: PCT/US2012/043785
Publication Date: 27.12.2012 International Filing Date: 22.06.2012
IPC:
A61K 31/095 (2006.01) ,A61K 31/517 (2006.01) ,A61K 31/433 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
095
Sulfur, selenium or tellurium compounds, e.g. thiols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
433
Thiadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US/US]; 200 First Street S.W. Rochester, Minnesota 55905, US (AllExceptUS)
REGENTS OF THE UNIVERSITY OF MINNESOTA [US/US]; 1000 Westgate Drive, Suite 160 Saint Paul, Minnesota 55114-8658, US (AllExceptUS)
ZHANG, Zhiguo [CN/US]; US (UsOnly)
LIMPER, Andrew, H. [US/US]; US (UsOnly)
HAN, Junhong [CN/US]; US (UsOnly)
ZHOU, Hui [CN/US]; US (UsOnly)
KOTTOM, Theodore, J. [US/US]; US (UsOnly)
HOOK, Derek [US/US]; US (UsOnly)
BERMAN, Judith [US/US]; US (UsOnly)
WALTERS, Michael, Anthony [US/US]; US (UsOnly)
Inventors:
ZHANG, Zhiguo; US
LIMPER, Andrew, H.; US
HAN, Junhong; US
ZHOU, Hui; US
KOTTOM, Theodore, J.; US
HOOK, Derek; US
BERMAN, Judith; US
WALTERS, Michael, Anthony; US
Agent:
GOODSON, Susanne, H.; Fish & Richardson P.C. P.O. Box 1022 Minneapolis, Minnesota 55440-1022, US
Priority Data:
61/499,94022.06.2011US
Title (EN) INHIBITORS OF RTT109 AS ANTI-FUNGAL AGENTS
(FR) INHIBITEURS DE RTT109 UTILISABLES EN TANT QU'AGENTS ANTIFONGIQUES
Abstract:
(EN) This document relates to materials and methods for identifying chemical inhibitors of fungal targets useful for treating organisms infected with opportunistic fungal pathogens. For example, this document provides the materials and methods for identifying and optimizing chemical inhibitors of Rtt109, a fungal histone acetyltransferase. This document also provides the materials and methods for using high throughput screening technologies to identify candidate chemical inhibitors of Rtt109 as well as the materials and methods for evaluating candidate chemical inhibitors of Rtt109 in secondary screens for their binding efficacy, molecular specificity, and cellular toxicity.
(FR) La présente invention concerne des substances et des procédés permettant d'identifier des inhibiteurs chimiques de cibles fongiques pouvant être utilisés en vue du traitement d'organismes infectés par des agents pathogènes fongiques opportunistes. La présente invention concerne, par exemple, les substances et les procédés permettant d'identifier et d'optimiser des inhibiteurs chimiques de Rtt109, une histone acétyltransférase fongique. La présente invention concerne également les substances et les procédés permettant d'utiliser des technologies de criblage à haut débit afin d'identifier des inhibiteurs chimiques potentiels de Rtt109, ainsi que les substances et les procédés permettant d'évaluer, dans le cadre de criblages secondaires, l'efficacité de liaison, la spécificité moléculaire et la toxicité cellulaire d'inhibiteurs chimiques potentiels de Rtt109.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)