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1. (WO2012177726) MICROORGANISM FOR PRODUCING PRIMARY ALCOHOLS AND RELATED COMPOUNDS AND METHODS RELATED THERETO
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/177726 International Application No.: PCT/US2012/043293
Publication Date: 27.12.2012 International Filing Date: 20.06.2012
IPC:
C12P 5/02 (2006.01) ,C12N 15/74 (2006.01) ,C12N 1/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
5
Preparation of hydrocarbons
02
acyclic
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
Applicants:
GENOMATICA, INC. [US/US]; 10520 Wateridge Circle San Diego, CA 92121, US (AllExceptUS)
BURGARD, Anthony, P. [US/US]; US (UsOnly)
OSTERHOUT, Robin, E. [US/US]; US (UsOnly)
SUN, Jun [CN/US]; US (UsOnly)
PHARKYA, Priti [IN/US]; US (UsOnly)
Inventors:
BURGARD, Anthony, P.; US
OSTERHOUT, Robin, E.; US
SUN, Jun; US
PHARKYA, Priti; US
Agent:
GAY, David, A.; Jones Day 222 East 41st Street New York, NY 10017-6702, US
Priority Data:
61/500,12122.06.2011US
61/502,81729.06.2011US
Title (EN) MICROORGANISM FOR PRODUCING PRIMARY ALCOHOLS AND RELATED COMPOUNDS AND METHODS RELATED THERETO
(FR) MICRO-ORGANISME POUR PRODUIRE DES ALCOOLS PRIMAIRES ET COMPOSÉS ASSOCIÉS ET PROCÉDÉS ASSOCIÉS À CEUX-CI
Abstract:
(EN) The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols and at least one exogenous nucleic acid that encodes an enzyme that increases the yields of the primary alcohol by (i) enhancing carbon fixation via the reductive TCA cycle, and/or (ii) accessing additional reducing equivalents from gaseous carbon sources and/or syngas components such as CO, C02, and/or H2. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.
(FR) L'invention concerne un organisme microbien d'origine non naturelle ayant un organisme microbien ayant au moins une insertion de gène exogène et/ou une ou plusieurs ruptures de gène qui confèrent la production d'alcools primaires et au moins un activité exogène qui code pour une enzyme qui augmente les rendements de l'alcool primaire par (i) augmentation de la fixation de carbone via le cycle TCA réducteur, et/ou (ii) accès à des équivalents réducteurs additionnels à partir de sources de carbone gazeuses et/ou des composants de gaz de synthèse tels que CO, CO2, et/ou H2. Un procédé pour produire des alcools à chaîne longue comprend la culture de ces organismes microbiens d'origine non naturelle.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2012273005