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1. (WO2012175591) HETEROCYCLYL AMINOIMIDAZOPYRIDAZINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/175591 International Application No.: PCT/EP2012/061927
Publication Date: 27.12.2012 International Filing Date: 21.06.2012
IPC:
C07D 487/04 (2006.01) ,A61K 31/425 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
Bayer Intellectual Property GmbH [DE/DE]; Alfred-Nobel-Str. 10 40789 Monheim, DE (AllExceptUS)
EIS, Knut [DE/DE]; DE (UsOnly)
PÜHLER, Florian [DE/DE]; DE (UsOnly)
ZORN, Ludwig [DE/DE]; DE (UsOnly)
SCHOLZ, Arne [DE/DE]; DE (UsOnly)
LIENAU, Philip [DE/DE]; DE (UsOnly)
GNOTH, Mark, Jean [NL/DE]; DE (UsOnly)
BÖMER, Ulf [DE/DE]; DE (UsOnly)
GÜNTHER, Judith [DE/DE]; DE (UsOnly)
FANGHÄNEL, Jörg [DE/CN]; CN (UsOnly)
KORR, Daniel [DE/DE]; DE (UsOnly)
Inventors:
EIS, Knut; DE
PÜHLER, Florian; DE
ZORN, Ludwig; DE
SCHOLZ, Arne; DE
LIENAU, Philip; DE
GNOTH, Mark, Jean; DE
BÖMER, Ulf; DE
GÜNTHER, Judith; DE
FANGHÄNEL, Jörg; CN
KORR, Daniel; DE
Agent:
BAYER INTELLECTUAL PROPERTY GmbH; Creative Campus Monheim Alfred-Nobel-Str. 10, Geb. 4865 40789 Monheim, DE
Priority Data:
11170861.622.06.2011EP
Title (EN) HETEROCYCLYL AMINOIMIDAZOPYRIDAZINES
(FR) HÉTÉROCYCLYLAMINOIMIDAZOPYRIDAZINES
Abstract:
(EN) The present invention relates to heterocyclyl aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
(FR) La présente invention porte sur des composés hétérocyclylaminoimidazopyridazines représentés par la formule générale (I) : dans laquelle A, R1, R2, R3 et R4 sont tels que définis dans les revendications, sur des procédés de préparation desdits composés, sur des compositions pharmaceutiques et des associations comprenant lesdits composés et sur l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique pour le traitement ou la prophylaxie d'une maladie, en particulier d'un trouble hyperprolifératif et/ou de l'angiogenèse, en tant qu'agent unique ou en association avec d'autres principes actifs.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2839958EP2723748CN103764656JP2014517053US20150038485ES2610366