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1. (WO2012175410) CONDITIONAL KNOCKOUT MUTANTS OF SORTILIN-LIKE RECEPTOR IN APICOMPLEXAN PARASITES AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/175410 International Application No.: PCT/EP2012/061385
Publication Date: 27.12.2012 International Filing Date: 14.06.2012
IPC:
A61K 35/68 (2006.01) ,C07K 14/705 (2006.01) ,C07K 14/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
68
Protozoa
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
44
from protozoa
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3, rue Michel-Ange F-75794 Paris Cedex 16, FR (AllExceptUS)
UNIVERSITE DE LILLE 2 [FR/FR]; 42, rue Paul Duez F-59800 Lille, FR (AllExceptUS)
I.N.S.E.R.M (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) [FR/FR]; 101, rue Tolbiac F-75654 Paris Cedex 13, FR (AllExceptUS)
TOMAVO, Stanislas [FR/FR]; FR (UsOnly)
SLOVES, Pierre-Julien [FR/FR]; FR (UsOnly)
MOUVEAUX, Thomas [FR/FR]; FR (UsOnly)
Inventors:
TOMAVO, Stanislas; FR
SLOVES, Pierre-Julien; FR
MOUVEAUX, Thomas; FR
Agent:
GROSSET-FOURNIER, Chantal; Grosset-Fournier & Demachy 54, rue Saint-Lazare F-75009 Paris, FR
Priority Data:
61/500,79024.06.2011US
Title (EN) CONDITIONAL KNOCKOUT MUTANTS OF SORTILIN-LIKE RECEPTOR IN APICOMPLEXAN PARASITES AND USES THEREOF
(FR) MUTANTS À INACTIVATION CONDITIONNELLE D'UN RÉCEPTEUR DE TYPE SORTILINE DANS DES PARASITES APICOMPLEXA ET LEURS UTILISATIONS
Abstract:
(EN) A nucleic acid construct which comprises a sequence of a 5' non-coding and promoter regions of Sortilin of an eukaryote organism, a selection gene cassette, said gene cassette having its own 5' and 3'UTR flanking sequence on both side of its coding sequence, a sequence of a 3' coding region of Sortilin of said eukaryote organism, said sequence being driven by an anhydrotetracycline(ATc)-sensitive transactivator and its use in human and veterinarian medicine.
(FR) L'invention concerne une construction d'acide nucléique qui comprend une séquence des régions 5' non codante et promotrice de Sortiline d'un organisme eucaryote, une cassette génique de sélection, ladite cassette génique ayant sa propre séquence flanquante 5' et 3'UTR sur les deux côtés de sa séquence codante, une séquence d'une région 3' codante de Sortiline dudit organisme eucaryote, ladite séquence étant commandée par un transactivateur sensible à l'anhydrotétracycline (ATc) et son utilisation en médecine humaine et vétérinaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2723355