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1. WO2012174437 - METHODS AND DEVICES FOR OPEN-BED ATMOSPHERIC COLLECTION FOR SUPERCRITICAL FLUID CHROMATOGRAPHY

Publication Number WO/2012/174437
Publication Date 20.12.2012
International Application No. PCT/US2012/042755
International Filing Date 15.06.2012
IPC
B01D 15/08 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
CPC
B01D 15/165
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
16relating to the conditioning of the fluid carrier
163Pressure or speed conditioning
165Flash chromatography
B01D 15/24
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
24relating to the treatment of the fractions to be distributed
B01D 15/247
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
24relating to the treatment of the fractions to be distributed
247Fraction collectors
B01D 15/40
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
40using supercritical fluid as mobile phase or eluent
G01N 2030/027
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
022characterised by the kind of separation mechanism
027Liquid chromatography
G01N 30/62
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
62Detectors specially adapted therefor
Applicants
  • WATERS TECHNOLOGIES CORPORATION [US]/[US] (AllExceptUS)
  • WANG, Ziqiang [US]/[US] (UsOnly)
  • ZULLI, Steve [US]/[US] (UsOnly)
  • ROLLE, Daniel [US]/[US] (UsOnly)
  • LUO, Chuping [CN]/[US] (UsOnly)
  • SIDHU, Harbaksh [US]/[US] (UsOnly)
Inventors
  • WANG, Ziqiang
  • ZULLI, Steve
  • ROLLE, Daniel
  • LUO, Chuping
  • SIDHU, Harbaksh
Agents
  • VERNON, Deborah M.
Priority Data
61/498,45817.06.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND DEVICES FOR OPEN-BED ATMOSPHERIC COLLECTION FOR SUPERCRITICAL FLUID CHROMATOGRAPHY
(FR) PROCÉDÉS ET DISPOSITIFS DESTINÉS À LA COLLECTE ATMOSPHÉRIQUE À LIT OUVERT POUR LA CHROMATOGRAPHIE EN PHASE FLUIDE SUPERCRITIQUE
Abstract
(EN)
A supercritical fluid chromatography system comprises a first pump for pumping a first flow stream comprising a compressible fluid and a second pump for pumping a second flow stream comprising a modifier fluid. The second pump is in parallel with the first pump. A column is located in a combined flow stream. The column is located downstream of the first and second pumps. The combined flow stream comprises the first flow stream, the second flow stream, and a sample. A detector is located downstream of the column. A gas-liquid separator is located downstream of the detector. The gas-liquid separator is configured to vent a majority of the compressible fluid while maintaining a majority of the sample, thus preventing aerosolization of the flow stream and minimizing sample loss as well as cross contamination. An open bed collector is located after the gas-liquid separator.
(FR)
L'invention concerne un système de chromatographie en phase fluide supercritique comprenant une première pompe pour pomper un premier flux d'écoulement comprenant un fluide compressible et une deuxième pompe pour pomper un deuxième flux d'écoulement comprenant un fluide de modification. La deuxième pompe est disposée en parallèle avec la première pompe. Une colonne est située dans un flux d'écoulement combiné. La colonne est située en aval de la première et de la deuxième pompe. Le flux d'écoulement combiné comprend le premier flux d'écoulement, le deuxième flux d'écoulement et un échantillon. Un détecteur est situé en aval de la colonne. Un séparateur gaz-liquide est situé en aval du détecteur. Le séparateur gaz-liquide est conçu pour évacuer une majorité du fluide compressible tout en conservant une majorité de l'échantillon, empêchant ainsi une aérosolisation du flux d'écoulement et minimisant la perte d'échantillon ainsi que la contamination croisée. Un collecteur à lit ouvert est situé après le séparateur gaz-liquide.
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