Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2012174392) METHODS OF TREATING RETROVIRAL INFECTIONS IN FELINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/174392 International Application No.: PCT/US2012/042693
Publication Date: 20.12.2012 International Filing Date: 15.06.2012
IPC:
C12N 5/16 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12
Fused cells, e.g. hybridomas
16
Animal cells
Applicants:
CYTODYN, INC. [US/US]; 110 Crenshaw Lake Road Lutz, FL 33548, US (AllExceptUS)
TRAUGER, Richard [US/US]; US (UsOnly)
Inventors:
TRAUGER, Richard; US
Agent:
EIDT, Chandra, E.; Miller Nash LLP 601 Union Street, Suite 4400 Seattle, WA 98101, US
Priority Data:
61/498,02917.06.2011US
Title (EN) METHODS OF TREATING RETROVIRAL INFECTIONS IN FELINES
(FR) MÉTHODES DE TRAITEMENT D'INFECTIONS RÉTROVIRALES CHEZ DES FÉLINS
Abstract:
(EN) Provided are methods for treating or reducing the likelihood of developing a retroviral infection in a feline, decreasing retroviral virion entry into a feline cell, decreasing retroviral virion budding from a feline cell, or decreasing syncytium transmission in a feline. These methods require the administration of at least one agent that specifically binds to CD11a and/or CD18, or ICAM-1, and/or decreases or prevents the binding of LFA-1 (CD11a/CD18 heterodimer) to ICAM-1. Also provided are veterinary compositions and methods of identifying candidate agents useful for treating or reducing retroviral infection in a feline, decreasing retroviral virion entry into a feline cell, decreasing retroviral virion budding from a feline cell, or decreasing syncytium transmission in a feline.
(FR) L'invention concerne des méthodes de traitement ou de réduction de la probabilité de développer une infection rétrovirale chez un félin, de diminution de l'entrée d'un virion rétroviral dans une cellule féline, de diminution du bourgeonnement d'un virion rétroviral provenant d'une cellule féline ou de diminution de la transmission de syncytium chez un félin. Ces méthodes nécessitent l'administration d'au moins un agent qui se lie spécifiquement à CD11a et/ou CD18 ou ICAM-1, et/ou diminue ou empêche la liaison de LFA-1 (hétérodimère CD11a/CD18) à ICAM-1. L'invention concerne également des compositions vétérinaires et des procédés d'identification d'agents candidats, utiles pour le traitement ou la réduction d'une infection rétrovirale chez un félin, de diminution de l'entrée d'un virion rétroviral dans une cellule féline, de diminution du bourgeonnement d'un virion rétroviral provenant d'une cellule féline ou de diminution de la transmission de syncytium chez un félin.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2839589EP2721147US20140140997