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1. (WO2012174338) METHOD OF SELECTING THERAPEUTIC INDICATIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/174338 International Application No.: PCT/US2012/042601
Publication Date: 20.12.2012 International Filing Date: 15.06.2012
IPC:
A61K 39/395 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED [GB/GB]; 980 Great West Road Brentford, Middlesex TW8 9GS, GB (AllExceptUS)
AGARWAL, Pankaj [US/US]; US (UsOnly)
CARDON, Lon, R. [US/US]; US (UsOnly)
MOOSER, Vincent, Eugene [CH/CH]; CH (UsOnly)
SANSEAU, Philippe [FR/GB]; GB (UsOnly)
Inventors:
AGARWAL, Pankaj; US
CARDON, Lon, R.; US
MOOSER, Vincent, Eugene; CH
SANSEAU, Philippe; GB
Agent:
LOCKENOUR, Andrea, V.; Glaxosmithkline Global Patents, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
61/497,30215.06.2011US
61/514,62303.08.2011US
Title (EN) METHOD OF SELECTING THERAPEUTIC INDICATIONS
(FR) PROCÉDÉ DE SÉLECTION D'INDICATIONS THÉRAPEUTIQUES
Abstract:
(EN) Methods are provided for repositioning a pharmaceutical, comprising the steps of: a. selecting at least one target gene or gene product associated with the treatment of at least one first disease, trait and/or phenotype by said pharmaceutical, b. identifying at least one second disease, trait and/or phenotype for at least one target gene of pharmaceutical mentioned in (a) using genome- wide associated studies, and c. selecting at least one second disease, trait and/or phenotype based on step (b) for treatment with said pharmaceutical compound in step (a). Methods are provided for treating Crohn's disease in a human in need thereof, comprising administering denosumab to said human.
(FR) L'invention concerne des procédés pour le repositionnement d'un produit pharmaceutique, comportant les étapes suivantes consistant à : a. sélectionner au moins un gène ou un produit de gène cible associé au traitement d'au moins une première maladie, un premier caractère et/ou un premier phénotype dudit produit pharmaceutique, b. identifier au moins une seconde maladie, un second caractère et/ou un second phénotype pour au moins un gène cible du produit pharmaceutique mentionné dans (a) à l'aide d'études associées au génome total, et c. sélectionner au moins une seconde maladie, un second caractère et/ou un second phénotype sur la base de l'étape (b) pour le traitement par ledit composé pharmaceutique dans l'étape (a). L'invention concerne des méthodes de traitement de la maladie de Crohn chez un être humain qui en a besoin, comportant l'administration de dénosumab audit être humain.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2841416EP2720719US20140170157