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1. (WO2012174327) COMBINATION THERAPIES FOR TREATING HEMATOLOGIC MALIGNANCIES USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K/MTOR WITH BENDAMUSTINE AND/OR RITUXIMAB
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/174327 International Application No.: PCT/US2012/042582
Publication Date: 20.12.2012 International Filing Date: 15.06.2012
IPC:
A61K 31/519 (2006.01) ,A61K 31/4184 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
EXELIXIS, INC. [US/US]; 210 East Grand Avenue South San Francisco, CA 94080, US (AllExceptUS)
SANOFI [FR/FR]; 54 rue La Boétie F-75008 Paris, FR (AllExceptUS)
DECILLIS, Arthur [US/US]; US (UsOnly)
LAGER, Joanne [US/US]; US (UsOnly)
ZAKS, Tal [US/US]; US (UsOnly)
Inventors:
DECILLIS, Arthur; US
LAGER, Joanne; US
ZAKS, Tal; US
Agent:
BERVEN, Heidi, M.; Honigman, Miller Schwartz and Cohn, LLP 350 East Michigan Avenue, Suite 300 Kalamazoo, MI 49007-3800, US
Priority Data:
125511401.06.2012FR
61/497,35615.06.2011US
61/510,32421.07.2011US
Title (EN) COMBINATION THERAPIES FOR TREATING HEMATOLOGIC MALIGNANCIES USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K/MTOR WITH BENDAMUSTINE AND/OR RITUXIMAB
(FR) POLYTHÉRAPIE DANS LE TRAITEMENT DE TUMEURS MALIGNES HÉMATOLOGIQUES, AU MOYEN D'INHIBITEURS DE PYRIDOPYRIMIDINONE DE PI3K/MTOR AVEC DE LA BENDAMUSTINE ET/OU DU RITUXIMAB
Abstract:
(EN) The invention provides a method for treating cancers including hematologic malignancies comprising administering a compound of Formula (I): in combination with one or both of bendamustine and rituximab.
(FR) La présente invention concerne un procédé de traitement de cancers incluant les tumeurs malignes hématologiques qui comprend l'administration d'un composé de formule (I): en association avec de la bendamustine et/ou du rituximab.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
JP2014517042US20140302012EP2793892RU2014101071BR112013032017