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1. (WO2012174178) ANTI-ANGPTL3 ANTIBODIES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/174178 International Application No.: PCT/US2012/042338
Publication Date: 20.12.2012 International Filing Date: 14.06.2012
IPC:
C07K 16/22 (2006.01) ,A61K 39/395 (2006.01) ,A61P 3/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
22
against growth factors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
Applicants:
SLEEMAN, Mark, W. [US/AU]; AU (UsOnly)
GUSAROVA, Viktoria [US/US]; US (UsOnly)
MURPHY, Andrew, J. [US/US]; US (UsOnly)
REGENERON PHARMACEUTICALS, INC [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591, US (AllExceptUS)
Inventors:
SLEEMAN, Mark, W.; AU
GUSAROVA, Viktoria; US
MURPHY, Andrew, J.; US
Agent:
COTTINGHAM, Frank; Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road Tarrytown, NY 10591, US
Priority Data:
61/498,51817.06.2011US
61/578,30921.12.2011US
Title (EN) ANTI-ANGPTL3 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-ANGPTL3 ET UTILISATIONS DE CEUX-CI
Abstract:
(EN) A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3) is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL3 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases; acute pancreatitis; nonalcoholic steatohepatitis (NASH); diabetes; obesity; and the like.
(FR) La présente invention concerne un anticorps totalement humain ou un fragment de liaison d'antigène d'un anticorps humain qui se lie spécifiquement à et inhibe ou interfère avec au moins une activité de la protéine similaire à l'angiopoïétine humaine 3 (hANGPTL3). Les anticorps anti-hANGPTL3 humain sont utiles dans le traitement de maladies ou troubles associés à ANGPTL3, tels que l'hyperlipidémie, l'hyperlipoprotéinémie et la dyslipidémie, comprenant l'hypertriglycéridémie, l'hypercholestérolémie, la chylomicronémie, etc. De plus, les anticorps anti-hANGPTL3 peuvent être administrés à un sujet nécessitant ceux-ci pour prévenir ou traiter des maladies ou troubles, pour lesquels un métabolisme anormal des lipides est un facteur de risque. De telles maladies ou de tels troubles comprennent les maladies cardiovasculaires, telles que l'athérosclérose et les maladies coronariennes ; la pancréatite aiguë ; la stéatose hépatique non alcoolique (NASH) ; le diabète ; l'obésité ; et similaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)