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1. (WO2012173555) COLLAGEN COATED ARTICLE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/173555 International Application No.: PCT/SE2012/050628
Publication Date: 20.12.2012 International Filing Date: 11.06.2012
IPC:
A61L 27/34 (2006.01) ,A61F 2/00 (2006.01) ,A61L 27/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
28
Materials for coating prostheses
34
Macromolecular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
24
Collagen
Applicants:
DENTSPLY IH AB [SE/SE]; Aminogatan 1 S-431 21 Mölndal, SE (AllExceptUS)
GRETZER, Christina [SE/SE]; SE (UsOnly)
MÖRGELIN, Matthias [DE/SE]; SE (UsOnly)
Inventors:
GRETZER, Christina; SE
MÖRGELIN, Matthias; SE
Agent:
AWAPATENT AB; Box 11394 S-404 28 Göteborg, SE
Priority Data:
11169676.113.06.2011EP
11171146.123.06.2011EP
61/496,27813.06.2011US
61/500,29423.06.2011US
Title (EN) COLLAGEN COATED ARTICLE
(FR) ARTICLE REVÊTU DE COLLAGÈNE
Abstract:
(EN) The invention provides a biocompatible article having a surface comprising collagen fibrils attached to said surface via one or more linker molecules, wherein each of said collagen fibrils is attached to at least one of said one or more linker molecules at a proximal end of the fibril, and wherein each of said collagen fibril has a proximal portion extending from said proximal end to a point P along said fibril, wherein, for a majority of said fibrils, each fibril at said point P is oriented so as to form an angle αP in the range of 0° to 45° to the surface normal N at the point of attachment of said fibril to said surface. The collagen fibril-coated surface has improved biocompatibility and is useful in a medical implant intended for implantation into soft tissue or bone tissue.
(FR) Cette invention concerne un article biocompatible ayant une surface portant des fibrilles de collagène fixées à ladite surface par l'intermédiaire d'une ou de plusieurs molécules liantes, chacune desdites fibrilles de collagène étant fixée à au moins une desdites molécules liantes ou plus à une extrémité proximale de la fibrille, et chacune des fibrilles de collagène ayant une partie proximale s'étendant à partir de ladite partie proximale jusqu'à un point P sur ladite fibrille. Pour une majorité desdites fibrilles, chaque fibrille audit point P est orientée de façon à former un angle αP dans la plage de 0 à 45° par rapport à la surface perpendiculaire N au point de fixation de ladite fibrille à ladite surface. La surface revêtue de fibrilles de collagène selon l'invention présente une biocompatibilité améliorée et est utile dans un implant médical destiné à être implanté dans un tissu mou ou un tissu osseux.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2717933