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1. (WO2012172887) THERAPEUTIC AGENT FOR HEART DISEASES AND CELL SHEET FOR TREATING HEART DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/172887 International Application No.: PCT/JP2012/061898
Publication Date: 20.12.2012 International Filing Date: 09.05.2012
Chapter 2 Demand Filed: 11.03.2013
IPC:
A61K 38/00 (2006.01) ,A61L 27/00 (2006.01) ,A61P 9/00 (2006.01) ,C12N 5/077 (2010.01) ,C07K 7/06 (2006.01) ,C12N 15/09 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
国立大学法人大阪大学 OSAKA UNIVERSITY [JP/JP]; 大阪府吹田市山田丘1番1号 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP (AllExceptUS)
濱田 吉之輔 HAMADA, Yoshinosuke [JP/JP]; JP (UsOnly)
松浦 成昭 MATSUURA, Nariaki [JP/JP]; JP (UsOnly)
澤 芳樹 SAWA, Yoshiki [JP/JP]; JP (UsOnly)
河口 直正 KAWAGUCHI, Naomasa [JP/JP]; JP (UsOnly)
宮川 繁 MIYAGAWA, Shigeru [JP/JP]; JP (UsOnly)
Inventors:
濱田 吉之輔 HAMADA, Yoshinosuke; JP
松浦 成昭 MATSUURA, Nariaki; JP
澤 芳樹 SAWA, Yoshiki; JP
河口 直正 KAWAGUCHI, Naomasa; JP
宮川 繁 MIYAGAWA, Shigeru; JP
Agent:
岩谷 龍 IWATANI, Ryo; 大阪府大阪市北区堂島2丁目1番31号 京阪堂島ビル3階 KEIHAN Dojima Bldg. 3F, 1-31, Dojima 2-chome, Kita-ku, Osaka-shi, Osaka 5300003, JP
Priority Data:
2011-13088913.06.2011JP
Title (EN) THERAPEUTIC AGENT FOR HEART DISEASES AND CELL SHEET FOR TREATING HEART DISEASES
(FR) AGENT THÉRAPEUTIQUE POUR MALADIES CARDIAQUES ET FEUILLET CELLULAIRE POUR TRAITER LES MALADIES CARDIAQUES
(JA) 心疾患治療薬および心疾患治療用細胞シート
Abstract:
(EN) It was discovered that a peptide having an amino acid sequence represented by formula (I), (II), (III), or (IV) has a cardiac function-improving effect. The peptide or a pharmaceutically acceptable salt thereof is useful as an active ingredient of a therapeutic agent for heart diseases. Further, when a cell sheet for treating heart diseases, which secretes the peptide, is transplanted into the heart suffering from a heart disease, the peptide can be allowed to act on the target site for a long time. X1-X2-Val-Tyr-X5-X6 (I) X2-Val-Tyr-X5-X6-X7 (II) Ser-X2-X3-(Tyr/Phe/Trp)-X5-X6 (III) X2-X3-(Tyr/Phe/Trp)-X5-X6-Arg (IV) In formulae (I), (II), (III), and (IV), X1, X2, X3, X5, X6, and X7 are the same or different and represent an arbitrary amino acid residue.
(FR) On a découvert qu'un peptide ayant une séquence d'acides aminés représentée par la formule (I), (II), (III), ou (IV) a un effet d'amélioration sur la fonction cardiaque. Le peptide ou un sel de qualité pharmaceutique de celui-ci est utile à titre de principe actif d'un agent thérapeutique destiné à traiter les maladies cardiaques. En outre, quand un feuillet cellulaire pour traiter des maladies cardiaques, qui sécrète le peptide, est transplanté dans un cœur atteint d'une maladie cardiaque, on peut laisser le peptide agir sur le site cible pendant longtemps. X1-X2-Val-Tyr-X5-X6 (I) X2-Val-Tyr-X5-X6-X7 (II) Ser-X2-X3-(Tyr/Phe/Trp)-X5-X6 (III) X2-X3-(Tyr/Phe/Trp)-X5-X6-Arg (IV). Dans les formules (I), (II), (III), et (IV), X1, X2, X3, X5, X6, et X7 sont identiques ou différents et représentent un résidu acide aminé arbitraire.
(JA)  下記式(I)、(II)、(III)または(IV)で表されるアミノ酸配列を有するペプチドが心機能改善作用を有することを見出した。当該ペプチドまたはその薬学的に許容される塩は心疾患治療薬の有効成分として有用である。また、当該ペプチドを分泌する心疾患治療用細胞シートを心疾患を発症した心臓に移植すれば、当該ペプチドを長期にわたり標的部位に作用させることができる。 X-X-Val-Tyr-X-X (I) X-Val-Tyr-X-X-X (II) Ser-X-X-(Tyr/Phe/Trp)-X-X (III) X-X-(Tyr/Phe/Trp)-X-X-Arg (IV) (式中X、X、X、X、XおよびXは、同一または異なって任意のアミノ酸残基を表す。)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
JPWO2012172887