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1. (WO2012172821) THERAPEUTIC AGENT FOR ALLERGIC RHINITIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/172821 International Application No.: PCT/JP2012/003945
Publication Date: 20.12.2012 International Filing Date: 15.06.2012
IPC:
A61K 31/197 (2006.01) ,A61K 9/06 (2006.01) ,A61K 9/08 (2006.01) ,A61K 41/00 (2006.01) ,A61P 11/02 (2006.01) ,A61P 37/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
02
Nasal agents, e.g. decongestants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
08
Antiallergic agents
Applicants:
SBIファーマ株式会社 SBI Pharmaceuticals Co., Ltd. [JP/JP]; 東京都港区六本木一丁目6番1号 6-1, Roppongi 1-chome, Minato-ku, Tokyo 1066020, JP (AllExceptUS)
独立行政法人 国立病院機構 National Hospital Organization [JP/JP]; 東京都目黒区東が丘2丁目5番21号 2-5-21 Higashigaoka, Meguro-ku, Tokyo 1528621, JP (AllExceptUS)
田中 徹 TANAKA, Tohru [JP/JP]; JP (UsOnly)
井上 克司 INOUE, Katsushi [JP/JP]; JP (UsOnly)
高橋 究 TAKAHASHI, Kiwamu [JP/JP]; JP (UsOnly)
石井 琢也 ISHII, Takuya [JP/JP]; JP (UsOnly)
沼田 勉 NUMATA, Tsutomu [JP/JP]; JP (UsOnly)
渋谷 真理子 SHIBUYA, Mariko [JP/JP]; JP (UsOnly)
鈴木 猛司 SUZUKI, Takeshi [JP/JP]; JP (UsOnly)
Inventors:
田中 徹 TANAKA, Tohru; JP
井上 克司 INOUE, Katsushi; JP
高橋 究 TAKAHASHI, Kiwamu; JP
石井 琢也 ISHII, Takuya; JP
沼田 勉 NUMATA, Tsutomu; JP
渋谷 真理子 SHIBUYA, Mariko; JP
鈴木 猛司 SUZUKI, Takeshi; JP
Agent:
廣田 雅紀 HIROTA, Masanori; 東京都港区赤坂二丁目2番19号 アドレスビル6階 6th Fl. Address Bldg., 2-2-19, Akasaka, Minato-ku, Tokyo 1070052, JP
Priority Data:
2011-13448916.06.2011JP
Title (EN) THERAPEUTIC AGENT FOR ALLERGIC RHINITIS
(FR) AGENT THÉRAPEUTIQUE POUR LA RHINITE ALLERGIQUE
(JA) アレルギー性鼻炎の治療剤
Abstract:
(EN) Provided is a therapeutic agent capable of treating allergic rhinitis in a safe, simple, and noninvasive manner substantially without side effects and physical pain to a patient. Provided is a therapeutic agent for allergic rhinitis for ALA-PDT that contains 5-aminolevulinic acid (ALA), a derivative thereof, or a salt thereof as an active ingredient, and that is used in 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) in which light having a wavelength of 400-700 nm is irradiated; and more particularly provided is a locally applied solution, a dissolving-type water-soluble ointment, a dissolving-type jelly agent, or another therapeutic agent for allergic rhinitis. This therapeutic agent does not require 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD) for detecting areas of protoporphyrin IX (PpIX) accumulation in which light having a wavelength of 610-650 nm is emitted under irradiation of excitation light having a wavelength of 380-420 nm prior to ALA-PDT.
(FR) L'invention porte sur un agent thérapeutique permettant de traiter la rhinite allergique en toute sécurité, d'une manière simple et non invasive pratiquement sans effets secondaires et sans douleur physique pour un patient. L'invention porte sur un agent thérapeutique pour la rhinite allergique pour la thérapie ALA-PDT qui contient de l'acide 5-aminolévulinique (ALA), un dérivé de celui-ci ou un sel de celui-ci en tant que principe actif et qui est utilisé en thérapie photodynamique à base d'acide 5-aminolévulinique (ALA-PDT) dans laquelle de la lumière ayant une longueur d'onde de 400-700 nm est utilisée ; et plus particulièrement, l'invention porte sur une solution appliquée localement, un onguent hydrosoluble de type dissolvant, un agent en gelée de type dissolvant ou un autre agent thérapeutique pour la rhinite allergique. Cet agent thérapeutique ne requiert pas de diagnostic photodynamique à base d'acide 5-aminolévulinique (ALA-PDD) pour la détection de zones d'accumulation de protoporphyrine IX (PpIX), dans lequel de la lumière ayant une longueur d'onde de 610-650 nm, est émise sous exposition à de la lumière d'excitation ayant une longueur d'onde de 380-420 nm, avant l'ALA-PDT.
(JA)  非侵襲性で副作用や患者への肉体的苦痛はほとんど無く、安全且つ簡単にアレルギー性鼻炎を治療することができる治療剤を提供するものである。5-アミノレブリン酸(ALA)若しくはその誘導体、又はそれらの塩を有効成分として含有し、400nm~700nmの波長の光を照射する5-アミノレブリン酸-光線力学的療法(ALA-PDT)において用いられる、ALA-PDTのためのアレルギー性鼻炎の治療剤、特に局所に塗布される溶液タイプ、水溶性軟膏溶解タイプ、ゼリー剤溶解タイプ等のアレルギー性鼻炎の治療剤を提供する。かかる治療剤は、ALA-PDTの前に、380nm~420nmの波長の励起光を照射して、610nm~650nmの波長を放射しているプロトポルフィリンIX(PpIX)蓄積部位を検出する5-アミノレブリン酸-光線力学的診断(ALA-PDD)を行うことを必要としない。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP2722041CN103717215US20140188034JPWO2012172821