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1. (WO2012171941) PREPARATION OF PET PRECURSOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/171941 International Application No.: PCT/EP2012/061165
Publication Date: 20.12.2012 International Filing Date: 13.06.2012
IPC:
C07C 269/06 (2006.01) ,C07B 59/00 (2006.01) ,C07C 271/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
by reactions not involving the formation of carbamate groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
24
with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
Applicants:
GE HEALTHCARE LIMITED [GB/GB]; Amersham Place Little Chalfont Buckinghamshire HP7 9NA, GB (AllExceptUS)
BERG, Tom, Christian [NO/NO]; NO (UsOnly)
Inventors:
BERG, Tom, Christian; NO
Agent:
BANNAN, Sally; GE Healthcare Limited Pollards Wood Nightingaled Lane Chafont St Giles Buckinghamshire HP8 4SP, GB
Priority Data:
61/496,59214.06.2011US
Title (EN) PREPARATION OF PET PRECURSOR
(FR) PRÉPARATION DE PRÉCURSEUR POUR PET
Abstract:
(EN) The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radio labelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-l-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent, wherein a hydrogenolysis is performed using a non-gaseous hydrogen source.
(FR) L'invention concerne un procédé de préparation de précurseurs radiopharmaceutiques, et en particulier des dérivés d'acides aminés protégés qui sont utilisés comme précurseurs dans la production d'acides aminés radiomarqués utilisés in vivo dans des procédures d'imagerie, telles qu'une tomographie par émission de positrons (PET). L'invention concerne en particulier un procédé de préparation d'un précurseur de l'agent PET d'acide [18F]-l-amino-3- fluorocyclobutanecarboxylique ([18F] FACBC), dans lequel une hydrogènolyse est effectuée au moyen d'une source d'hydrogène non gazeux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2758368ES2546997DK2758368