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1. (WO2012171903) NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C]ISOQUINOLINE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/171903 International Application No.: PCT/EP2012/061091
Publication Date: 20.12.2012 International Filing Date: 12.06.2012
IPC:
C07D 495/04 (2006.01) ,C07D 519/00 (2006.01) ,A61K 31/519 (2006.01) ,A61P 11/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
TAKEDA GMBH [DE/DE]; Byk-Gulden-Str. 2 78467 Konstanz, DE (AllExceptUS)
FLOCKERZI, Dieter [DE/DE]; DE (UsOnly)
MANN, Alexander [DE/DE]; DE (UsOnly)
STENGEL, Thomas [DE/DE]; DE (UsOnly)
OHMER, Harald [DE/DE]; DE (UsOnly)
KAUTZ, Ulrich [DE/DE]; DE (UsOnly)
WEINBRENNER, Steffen [DE/DE]; DE (UsOnly)
FISCHER, Stefan [DE/DE]; DE (UsOnly)
TENOR, Hermann [DE/DE]; DE (UsOnly)
ZITT, Christof [DE/DE]; DE (UsOnly)
HATZELMANN, Armin [DE/DE]; DE (UsOnly)
DUNKERN, Torsten [DE/DE]; DE (UsOnly)
HESSLINGER, Christian [DE/DE]; DE (UsOnly)
BRAUN, Clemens [DE/DE]; DE (UsOnly)
BENEDIKTUS, Ewald [DE/DE]; DE (UsOnly)
PAHL, Andreas [DE/DE]; DE (UsOnly)
KÜLZER, Raimund [DE/DE]; DE (UsOnly)
MARX, Degenhard [DE/DE]; DE (UsOnly)
Inventors:
FLOCKERZI, Dieter; DE
MANN, Alexander; DE
STENGEL, Thomas; DE
OHMER, Harald; DE
KAUTZ, Ulrich; DE
WEINBRENNER, Steffen; DE
FISCHER, Stefan; DE
TENOR, Hermann; DE
ZITT, Christof; DE
HATZELMANN, Armin; DE
DUNKERN, Torsten; DE
HESSLINGER, Christian; DE
BRAUN, Clemens; DE
BENEDIKTUS, Ewald; DE
PAHL, Andreas; DE
KÜLZER, Raimund; DE
MARX, Degenhard; DE
Agent:
WILD, Robert; Takeda GmbH P.O. Box 100310 78403 Konstanz, DE
Priority Data:
11169908.815.06.2011EP
61/536,81020.09.2011US
Title (EN) NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C]ISOQUINOLINE COMPOUNDS
(FR) NOUVEAUX COMPOSÉS DE 3,4,4A,10B-TÉTRAHYDRO-1H-THIOPYRANO[4,3-C]ISOQUINOLÉINE
Abstract:
(EN) The compounds of formula (1), in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
(FR) L'invention porte sur les composés de formule (1), dans laquelle A, X, R1, R2, R3 et R7 ont les significations telles que données dans la description, lesquels composés sont de nouveaux inhibiteurs efficaces de la phosphodiestérase de type 4 et de type 5.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2721036US20140113877JP2014519519