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1. (WO2012171135) BENZOFURAN COMPOUND, PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/171135 International Application No.: PCT/CN2011/000979
Publication Date: 20.12.2012 International Filing Date: 13.06.2011
IPC:
C07D 307/80 (2006.01) ,A61K 31/343 (2006.01) ,A61P 9/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Benzo [b] furans; Hydrogenated benzo [b] furans
79
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
80
Radicals substituted by oxygen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343
condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
山东邹平大展新材料有限公司 SHANDONG ZOUPING DAZHAN NEW MATERIAL CO., LTD. [CN/CN]; 中国山东省邹平县临池镇小临池村 Xiaolinchi Village Linchi Zouping Shandong 256220, CN (AllExceptUS)
李岩 LI, Yan [CN/CN]; CN (UsOnly)
林泉生 LIN, Quansheng [CN/CN]; CN (UsOnly)
Inventors:
李岩 LI, Yan; CN
林泉生 LIN, Quansheng; CN
Agent:
济南舜源专利事务所有限公司 JINAN SHUNYUAN PATENT AGENCY CO., LTD.; 中国山东省济南市 历下区经十东路157号 No. 157 Jingshidong Road, Lixia District Jinan, Shandong 250014, CN
Priority Data:
Title (EN) BENZOFURAN COMPOUND, PREPARATION METHOD AND USE THEREOF
(FR) COMPOSÉ DE BENZOFURANE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一种苯并呋喃化合物、其制备方法及用途
Abstract:
(EN) Disclosed are a benzofuran compound of formula (I), its preparation method and its use as intermediate in preparing dronedarone. High yield, high product purity and low production cost are achieved when dronedarone is synthesized by using the said compound. It is easy to control, and high efficient production of dronedarone can be realized in large scale.
(FR) L'invention concerne un composé de benzofurane de formule (I), son procédé de préparation et son utilisation en tant qu'intermédiaire pour la préparation de dronédarone. Un rendement élevé, une grande pureté de produit et un faible coût de production sont obtenus lorsque la dronédarone est synthétisée en utilisant ledit composé. Il est facile à contrôler, et une production hautement efficace de dronédarone peut être réalisée à grande échelle.
(ZH) 公开了一种式(I)的苯并呋喃化合物,其制备方法以及其用作中间体制备决奈达隆的用途。使用所述化合物合成决奈达隆的收率高,产品纯度高,生产成本低,且易于控制,可以实现决奈达隆的高效、大规模生产。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)