Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2012170889) CLEAVABLE LIPIDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/170889 International Application No.: PCT/US2012/041663
Publication Date: 13.12.2012 International Filing Date: 08.06.2012
IPC:
C07D 233/64 (2006.01) ,C07C 323/00 (2006.01) ,A61K 9/127 (2006.01) ,A61K 31/4164 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
64
with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
Applicants:
SHIRE HUMAN GENETIC THERAPIES, INC. [US/US]; 300 Shire Way Lexington, MA 02421, US (AllExceptUS)
HEARTLEIN, Michael [US/US]; US (UsOnly)
GUILD, Braydon, Charles [US/US]; US (UsOnly)
DEROSA, Frank [US/US]; US (UsOnly)
ZHANG, Jerry, Chi [US/US]; US (UsOnly)
Inventors:
HEARTLEIN, Michael; US
GUILD, Braydon, Charles; US
DEROSA, Frank; US
ZHANG, Jerry, Chi; US
Agent:
CHEN, Fangli; Choate, Hall & Stewart LLP Two International Place Boston, Massachusetts 02110, US
Priority Data:
61/494,74508.06.2011US
61/494,88208.06.2011US
Title (EN) CLEAVABLE LIPIDS
(FR) LIPIDES CLIVABLES
Abstract:
(EN) Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
(FR) Cette invention concerne de nouveaux composés, de nouvelles compositions pharmaceutiques comprenant ces composés et des méthodes d'utilisation associées. Les composés décrits ici sont utilisés, par exemple, comme véhicules d'administration de liposomes pour faciliter l'administration de polynucléotides encapsulés dans des cellules cibles et la transfection consécutive desdites cellules cibles; dans certains modes de réalisation, ces composés se caractérisent comme ayant un ou plusieurs avantages par rapport à des lipides similaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2838063CN103748078JP2014523870EP2718269US20140288160AU2012267578
IN10971/DELNP/2013ES2663360