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1. WO2012168359 - COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

Publication Number WO/2012/168359
Publication Date 13.12.2012
International Application No. PCT/EP2012/060795
International Filing Date 07.06.2012
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
04
with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring system
06
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
439
the ring forming part of a bridged ring system, e.g. quinuclidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
08
Bronchodilators
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
213
Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
10
Separation; Purification; Stabilisation; Use of additives
C07D 401/12 (2006.01)
C07D 451/06 (2006.01)
C07D 453/02 (2006.01)
A61K 31/439 (2006.01)
A61K 31/4709 (2006.01)
A61P 11/06 (2006.01)
CPC
A61K 31/428
A61K 31/439
A61K 31/4525
A61K 31/4704
A61K 31/4709
A61K 9/0073
Applicants
  • CHIESI FARMACEUTICI S.p.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT (AllExceptUS)
  • RANCATI, Fabio [IT/IT]; IT (UsOnly)
  • RIZZI, Andrea [IT/IT]; IT (UsOnly)
  • AMARI, Gabriele [IT/IT]; IT (UsOnly)
  • BIAGETTI, Matteo [IT/IT]; IT (UsOnly)
  • LINNEY, Ian [GB/IT]; IT (UsOnly)
Inventors
  • RANCATI, Fabio; IT
  • RIZZI, Andrea; IT
  • AMARI, Gabriele; IT
  • BIAGETTI, Matteo; IT
  • LINNEY, Ian; IT
Agents
  • MINOJA, Fabrizio; Via Plinio, 63 I-20129 Milano, IT
Priority Data
11169537.510.06.2011EP
12165283.824.04.2012EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
(FR) COMPOSÉS AYANT UNE ACTIVITÉ ANTAGONISTE D'UN RÉCEPTEUR MUSCARINIQUE ET AGONISTE D'UN RÉCEPTEUR BÊTA2 ADRÉNERGIQUE
Abstract
(EN)
The present invention relates to compounds acting both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists, to processes for their preparation, to compositions comprising them, to therapeutic uses and combinations with other pharmaceutical active ingredients.
(FR)
La présente invention concerne des composés agissant à la fois en tant qu'antagonistes d'un récepteur muscarinique et agonistes d'un récepteur bêta2 adrénergique, des procédés pour leur préparation, des compositions les comprenant, des utilisations thérapeutiques et des combinaisons avec d'autres principes actifs pharmaceutiques.
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