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1. (WO2012164512) METHOD FOR PRODUCING THREE-DIMENSIONAL MONOLITHIC MICROFLUIDIC DEVICES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/164512 International Application No.: PCT/IB2012/052732
Publication Date: 06.12.2012 International Filing Date: 31.05.2012
IPC:
G03F 7/00 (2006.01) ,B81C 1/00 (2006.01)
G PHYSICS
03
PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
F
PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
7
Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
C
PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICRO-STRUCTURAL DEVICES OR SYSTEMS
1
Manufacture or treatment of devices or systems in or on a substrate
Applicants:
FONDAZIONE FILARETE PER LE BIOSCIENZE E L'INNOVAZIONE [IT/IT]; Viale Ortles 22/4 I-20139 Milano, IT (AllExceptUS)
LENARDI, Cristina [IT/IT]; IT (UsOnly)
TOCCHIO, Alessandro [IT/IT]; IT (UsOnly)
MARTELLO, Federico [IT/IT]; IT (UsOnly)
Inventors:
LENARDI, Cristina; IT
TOCCHIO, Alessandro; IT
MARTELLO, Federico; IT
Agent:
PALLADINO, Saverio Massimo; Corso di Porta Vittoria 9 I-20122 Milano, IT
Priority Data:
MI2011A00099531.05.2011IT
Title (EN) METHOD FOR PRODUCING THREE-DIMENSIONAL MONOLITHIC MICROFLUIDIC DEVICES
(FR) PROCÉDÉ DE FABRICATION DE DISPOSITIFS MICROFLUIDIQUES MONOLITHIQUES TRIDIMENSIONNELS
Abstract:
(EN) A method is described for producing a microfluidic device (19), which comprises the phases of producing a three-dimensional template (15) of geometry equal to the channelings that is desired to obtain in the device; inserting the template in the desired position into a mould (16), keeping it suspended by at least one of its end; coating said template by immersion in (or deposition of) a material in the liquid phase (or dissolved or dispersed in a solvent) capable of solidifying by means of a chemical reaction or physical transformation, forming a material constituting the body of the final device; and selectively removing the three-dimensional template. In a variant of the method, useful for the production of scaffolds to be inserted into the human body, a porogenic material is added to the liquid precursor or to the precursor solution, such that the material of the solid matrix is characterised by a continuous structure of pores into which it is possible to insert live cells.
(FR) L'invention concerne un procédé de fabrication d'un dispositif microfluidique (19), qui comprend les phases de production d'une matrice tridimensionnelle (15) de géométrie égale aux canalisations que l'on souhaite obtenir dans le dispositif ; d'introduction de la matrice dans la position souhaitée dans un moule (16), en la gardant suspendue par au moins l'une de ses extrémités ; de revêtement de ladite matrice par immersion dans (ou dépôt de) une matière dans la phase liquide (ou dissoute ou dispersée dans un solvant), susceptible d'une solidification au moyen d'une réaction chimique ou d'une transformation physique, formant une matière constituant le corps du dispositif final ; et d'élimination sélective de la matrice tridimensionnelle. Dans une variante du procédé, utile pour la fabrication d'échafaudages devant être introduits dans le corps humain, une matière porogène est ajoutée au précurseur liquide ou à la solution de précurseur, de telle sorte que la matière de la matrice solide est caractérisée en ce qu'elle a une structure continue de pores dans lesquels il est possible d'introduire des cellules vivantes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Italian (IT)
Also published as:
CA2838018EP2715450US20140106454IL229746ES2692296