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1. WO2012164495 - A METHOD AND A SYSTEM FOR EVALUATING VASCULAR ENDOTHELIUM FUNCTION

Publication Number WO/2012/164495
Publication Date 06.12.2012
International Application No. PCT/IB2012/052691
International Filing Date 30.05.2012
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
02
Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026
Measuring blood flow
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
145
Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
1455
using optical sensors, e.g. spectral photometrical oximeters
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
02
Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
02
Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
024
Measuring pulse rate or heart rate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
145
Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
A61B 5/026 (2006.01)
A61B 5/1455 (2006.01)
A61B 5/02 (2006.01)
A61B 5/024 (2006.01)
A61B 5/145 (2006.01)
CPC
A61B 5/0071
A61B 5/02007
A61B 5/02422
A61B 5/0261
A61B 5/14546
A61B 5/14556
Applicants
  • POLITECHNIKA ŁÓDZKA [PL/PL]; ul. Żeromskiego 116 PL-90-924 Łódź, PL (AllExceptUS)
  • UNIWERSYTET JAGIELLOŃSKI [PL/PL]; ul. Gołębia 24 PL-31-007 Kraków, PL (AllExceptUS)
  • GĘBICKI, Jerzy [PL/PL]; PL (UsOnly)
  • MARCINEK, Andrzej [PL/PL]; PL (UsOnly)
  • CHŁOPICKI, Stefan [PL/PL]; PL (UsOnly)
Inventors
  • GĘBICKI, Jerzy; PL
  • MARCINEK, Andrzej; PL
  • CHŁOPICKI, Stefan; PL
Agents
  • SITKOWSKA, Jadwiga; Al. Komisji Edukacji Narodowej 83/106 PL-02-777 Warszawa, PL
Priority Data
61/491,54331.05.2011US
PL39507431.05.2011PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD AND A SYSTEM FOR EVALUATING VASCULAR ENDOTHELIUM FUNCTION
(FR) PROCÉDÉ ET SYSTÈME POUR ÉVALUER LA FONCTION DE L'ENDOTHÉLIUM VASCULAIRE
Abstract
(EN)
A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.
(FR)
L'invention concerne un procédé pour évaluer la fonction de l'endothélium vasculaire chez un sujet humain, lequel procédé consiste à surveiller des changements de l'intensité d'un signal de fluorescence du NADH provenant de cellules du tissu de la peau d'un membre supérieur dudit sujet en fonction du temps, lesdits changements résultant d'une hyperémie réactive provoquée par le blocage et la libération d'un écoulement de sang dans le même membre supérieur dudit sujet. Un système pour évaluer la fonction de l'endothélium vasculaire chez un sujet humain comprend un moyen pour éclairer une peau sur un membre supérieur dudit sujet avec une lumière d'excitation, un moyen pour mesurer l'intensité d'un signal de fluorescence émis par la peau et enregistrer des changements de ladite intensité du signal de fluorescence au cours du temps; et un moyen de limitation pour bloquer et libérer l'écoulement de sang dans le membre supérieur dudit sujet.
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