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1. WO2012164495 - A METHOD AND A SYSTEM FOR EVALUATING VASCULAR ENDOTHELIUM FUNCTION

Publication Number WO/2012/164495
Publication Date 06.12.2012
International Application No. PCT/IB2012/052691
International Filing Date 30.05.2012
IPC
A61B 5/026 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026Measuring blood flow
A61B 5/1455 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
1455using optical sensors, e.g. spectral photometrical oximeters
A61B 5/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/024 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
024Measuring pulse rate or heart rate
A61B 5/145 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
CPC
A61B 5/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0071by measuring fluorescence emission
A61B 5/02007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02007Evaluating blood vessel condition, e.g. elasticity, compliance
A61B 5/02422
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
024Detecting, measuring or recording pulse rate or heart rate
02416using photoplethysmograph signals, e.g. generated by infra-red radiation
02422within occluders
A61B 5/0261
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
026Measuring blood flow
0261using optical means, e.g. infra-red light
A61B 5/14546
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
14546for measuring analytes not otherwise provided for, e.g. ions, cytochromes
A61B 5/14556
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
14551for measuring blood gases
14556by fluorescence
Applicants
  • POLITECHNIKA ŁÓDZKA [PL]/[PL] (AllExceptUS)
  • UNIWERSYTET JAGIELLOŃSKI [PL]/[PL] (AllExceptUS)
  • GĘBICKI, Jerzy [PL]/[PL] (UsOnly)
  • MARCINEK, Andrzej [PL]/[PL] (UsOnly)
  • CHŁOPICKI, Stefan [PL]/[PL] (UsOnly)
Inventors
  • GĘBICKI, Jerzy
  • MARCINEK, Andrzej
  • CHŁOPICKI, Stefan
Agents
  • SITKOWSKA, Jadwiga
Priority Data
61/491,54331.05.2011US
PL39507431.05.2011PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD AND A SYSTEM FOR EVALUATING VASCULAR ENDOTHELIUM FUNCTION
(FR) PROCÉDÉ ET SYSTÈME POUR ÉVALUER LA FONCTION DE L'ENDOTHÉLIUM VASCULAIRE
Abstract
(EN)
A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.
(FR)
L'invention concerne un procédé pour évaluer la fonction de l'endothélium vasculaire chez un sujet humain, lequel procédé consiste à surveiller des changements de l'intensité d'un signal de fluorescence du NADH provenant de cellules du tissu de la peau d'un membre supérieur dudit sujet en fonction du temps, lesdits changements résultant d'une hyperémie réactive provoquée par le blocage et la libération d'un écoulement de sang dans le même membre supérieur dudit sujet. Un système pour évaluer la fonction de l'endothélium vasculaire chez un sujet humain comprend un moyen pour éclairer une peau sur un membre supérieur dudit sujet avec une lumière d'excitation, un moyen pour mesurer l'intensité d'un signal de fluorescence émis par la peau et enregistrer des changements de ladite intensité du signal de fluorescence au cours du temps; et un moyen de limitation pour bloquer et libérer l'écoulement de sang dans le membre supérieur dudit sujet.
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