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1. (WO2012164058) METHODS FOR ADJUSTING EXPRESSION OF MITOCHONDRIAL GENOME BY MICRORNA

Pub. No.:    WO/2012/164058    International Application No.:    PCT/EP2012/060336
Publication Date: Fri Dec 07 00:59:59 CET 2012 International Filing Date: Sat Jun 02 01:59:59 CEST 2012
IPC: C12N 15/113
Applicants: INSERM (Institut National de la Santé et de la Recherche Médicale)
HENRION-CAUDE, Alexandra
BANDIERA, Simonetta
LYONNET, Stanislas
Inventors: HENRION-CAUDE, Alexandra
BANDIERA, Simonetta
LYONNET, Stanislas
Title: METHODS FOR ADJUSTING EXPRESSION OF MITOCHONDRIAL GENOME BY MICRORNA
Abstract:
The present invention relates to a method for adjusting the expression of the mitochondrial genome in a human cell comprising a step consisting of modulating the expression of a least one mi RNA selected from the group consisting of hsa-mi R-1973, hsa-mi R-1275, hsa-mi R-494, hsa-mi R-513a-5p, hsa-mi R-1246, hsa-mi R-328, hsa-mi R-1908, hsa-mi R-1972, hsa-mi R-1974, hsa-mi R-1977, hsa-mi R-638, hsa-mi R-1978 and hsa-mi R-1201.