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1. WO2012154679 - TRICYCLIC PYRAZOLE SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Publication Number WO/2012/154679
Publication Date 15.11.2012
International Application No. PCT/US2012/036793
International Filing Date 07.05.2012
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5383
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
C07D 471/04 (2006.01)
C07D 498/04 (2006.01)
A61K 31/5383 (2006.01)
A61P 3/04 (2006.01)
CPC
A61K 31/4745
A61K 31/5383
A61K 9/0053
C07D 471/04
C07D 498/04
C07D 498/14
Applicants
  • ZAFGEN, INC. [US/US]; One Broadway, 8th Floor Cambridge, Massachusetts 02142, US (AllExceptUS)
  • CRAMP, Susan, Mary [GB/GB]; GB (UsOnly)
  • DYKE, Hazel, Joan [GB/GB]; GB (UsOnly)
  • PALLIN, Thomas, David [GB/GB]; GB (UsOnly)
  • ZAHLER, Robert [US/US]; US (UsOnly)
Inventors
  • CRAMP, Susan, Mary; GB
  • DYKE, Hazel, Joan; GB
  • PALLIN, Thomas, David; GB
  • ZAHLER, Robert; US
Agents
  • KAVANAUGH, Theresa, C.; Goodwin Procter LLP Exchange Place Boston, MA 02109, US
Priority Data
61/483,27506.05.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC PYRAZOLE SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
(FR) COMPOSÉS DE SULFONAMIDE PYRAZOLE TRICYCLIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract
(EN)
The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
(FR)
L'invention concerne des composés de sulfonamide tricycliques et leur utilisation dans le traitement de troubles médicaux tels que l'obésité. L'invention concerne également des compositions pharmaceutiques et des procédés de fabrication de divers composés tricycliques. Ces composés sont sensés avoir une activité contre la méthionylaminopeptidase 2.
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