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1. WO2012146659 - NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Publication Number WO/2012/146659
Publication Date 01.11.2012
International Application No. PCT/EP2012/057654
International Filing Date 26.04.2012
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4162
condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
C07D 471/04 (2006.01)
A61K 31/4162 (2006.01)
A61P 19/02 (2006.01)
CPC
A61K 31/437
A61K 31/496
A61K 31/5377
A61K 31/541
A61K 45/06
C07D 471/04
Applicants
  • GALAPAGOS NV [BE/BE]; Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
  • MENET, Christel, Jeanne, Marie [FR/BE]; BE (UsOnly)
  • HODGES, Alastair, James [GB/GB]; GB (UsOnly)
  • VATER, Huw, David [GB/GB]; GB (UsOnly)
Inventors
  • MENET, Christel, Jeanne, Marie; BE
  • HODGES, Alastair, James; GB
  • VATER, Huw, David; GB
Agents
  • NICHOL, Maria; Galapagos NV Chesterford Research Park Saffron Walden Essex CB10 1XL, GB
Priority Data
61/479,95628.04.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
(FR) NOUVEAU COMPOSÉ UTILE POUR LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
Abstract
(EN)
Novel pyrrazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prophylaxis and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.
(FR)
La présente invention concerne de nouvelles pyrrazolopyridines de formule I, pouvant inhiber la kinase JAK. Ces composés peuvent être préparés sous forme de composition pharmaceutique, et peuvent être utilisés pour la prophylaxie et le traitement d'une variété de pathologies chez les mammifères dont les humains, comprenant entre autres, l'allergie, les pathologies inflammatoires, les maladies auto-immunes, les maladies prolifératives, le rejet de greffe, les maladies impliquant une déficience du renouvellement du cartilage, des malformations congénitales du cartilage, et/ou des maladies associées à l'hyper-sécrétion d'IL6 ou d'interférons.
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