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1. WO2012145169 - FUNCTIONALIZED MAGNETIC NANOPARTICLES AND USE IN IMAGING AMYLOID DEPOSITS AND NEUROFIBRILLARY TANGLES

Publication Number WO/2012/145169
Publication Date 26.10.2012
International Application No. PCT/US2012/032100
International Filing Date 04.04.2012
IPC
A61B 5/055 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
05Measuring for diagnosis by means of electric currents or magnetic fields
055involving electronic or nuclear magnetic resonance, e.g. magnetic resonance imaging
CPC
A61K 31/132
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
132having two or more amino groups, e.g. spermidine, putrescine
A61K 31/133
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
133having hydroxy groups, e.g. sphingosine
A61K 31/136
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
136having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
145having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
275Nitriles; Isonitriles
277having a ring, e.g. verapamil
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • AKHTARI, Massoud [US]/[US] (UsOnly)
Inventors
  • AKHTARI, Massoud
Agents
  • BORDEN, Paula A.
Priority Data
61/477,95821.04.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUNCTIONALIZED MAGNETIC NANOPARTICLES AND USE IN IMAGING AMYLOID DEPOSITS AND NEUROFIBRILLARY TANGLES
(FR) NANOPARTICULES MAGNÉTIQUES FONCTIONNALISÉES ET LEUR UTILISATION DANS L'IMAGERIE DE DÉPÔTS AMYLOÏDES ET D'ENCHEVÊTREMENTS NEUROFIBRILLAIRES
Abstract
(EN)
The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging β-amyloid deposits and neurofibrillary tangles.
(FR)
L'invention concerne des nanoparticules magnétiques fonctionnalisées (MNP) comprenant un groupe fonctionnel se liant à des dépôts β-amyloïdes et/ou des enchevêtrements neurofibrillaires. L'invention concerne également des compositions contenant les nanoparticules magnétiques fonctionnalisées et l'utilisation des nanoparticules magnétiques fonctionnalisées dans l'imagerie de dépôts β-amyloïdes et/ou d'enchevêtrements neurofibrillaires.
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