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1. WO2012144711 - COMPOSITION CONTAINING CARYOPTERIS INCANA EXTRACTS OR A COMPOUND ISOLATED THEREFROM FOR PREVENTING AND TREATING HEPATOTOXICITY

Publication Number WO/2012/144711
Publication Date 26.10.2012
International Application No. PCT/KR2011/008964
International Filing Date 23.11.2011
IPC
A61K 36/85 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
85Verbenaceae (Verbena family)
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 1/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
CPC
A61K 36/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • 한국과학기술연구원 KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY [KR]/[KR] (AllExceptUS)
  • 진창배 JIN, Chang Bae [KR]/[KR] (UsOnly)
  • 김형자 KIM, Hyoung Ja [KR]/[KR] (UsOnly)
  • 이용섭 LEE, Yong Sup [KR]/[KR] (UsOnly)
  • 정서윤 JUNG, Suh Yun [KR]/[KR] (UsOnly)
Inventors
  • 진창배 JIN, Chang Bae
  • 김형자 KIM, Hyoung Ja
  • 이용섭 LEE, Yong Sup
  • 정서윤 JUNG, Suh Yun
Agents
  • 한라특허법인 HALLA PATENT&LAW FIRM
Priority Data
10-2011-003686620.04.2011KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION CONTAINING CARYOPTERIS INCANA EXTRACTS OR A COMPOUND ISOLATED THEREFROM FOR PREVENTING AND TREATING HEPATOTOXICITY
(FR) COMPOSITION CONTENANT DES EXTRAITS DE CARYOPTERIS INCANA OU UN COMPOSÉ ISOLÉ À PARTIR DE CEUX-CI POUR PRÉVENIR ET TRAITER L'HÉPATOTOXICITÉ
(KO) 층꽃풀 추출물 또는 이로부터 분리된 화합물을 함유하는 간독성 질환 예방 및 치료용 조성물
Abstract
(EN)
The present invention relates to a composition containing Caryopteris incana extracts or a compound isolated therefrom for preventing and treating hepatotoxicity. The Caryopteris incana extracts, fractions thereof, and a compound isolated therefrom provide excellent effects in protecting hepatocytes when hepatotoxicity is induced by toxic substances such as tertiary-butyl hydroperoxide (t-BHP), and thus the provision of excellent effects in preventing and treating liver disorders can be expected.
(FR)
La présente invention concerne une composition contenant des extraits de Caryopteris incana ou un composé isolé à partir de ceux-ci pour prévenir et traiter l'hépatotoxicité. Les extraits de Caryopteris incana, des fractions de ceux-ci et un composé isolé à partir de ceux-ci fournissent d'excellents effets dans la protection des hépatocytes lorsqu'une hépatotoxicité est induite par des substances toxiques telles que l'ydroperoxyde de tert.-butyle (t-BHP), et de ce fait, on peut s'attendre à ce que d'excellents effets dans la prévention et le traitement de troubles du foie soient fournis.
(KO)
본 발명은 층꽃풀 추출물, 이의 분획물 또는 이로부터 분리된 화합물을 함유하는 간독성 질환 예방 및 치료용 조성물에 관한 것이다. 본 발명의 층꽃풀(Caryopteris incana) 추출물, 이의 분획물 및 이로부터 분리된 화합물은 제3급-부틸히드로퍼옥시드(t-BHP, tertiary-butyl hydroperoxide)와 같은 독성 물질에 의하여 간 독성이 유발되었을 때 간세포 보호 효과가 우수하므로 간 질환의 예방 및 치료에 탁월한 효과를 기대할 수 있다.
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