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1. (WO2012143523) BISPECIFC ANTIBODIES AGAINST HER2
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/143523 International Application No.: PCT/EP2012/057303
Publication Date: 26.10.2012 International Filing Date: 20.04.2012
IPC:
A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C07K 16/32 (2006.01) ,C07K 16/10 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
10
from RNA viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
Applicants:
GENMAB A/S [DK/DK]; Bredgade 34 E DK-1260 Copenhagen K, DK (AllExceptUS)
DE GOEIJ, Bart [NL/NL]; NL (UsOnly)
VAN BERKEL, Patrick [NL/NL]; NL (UsOnly)
STRUMANE, Kristin [NL/NL]; NL (UsOnly)
LABRIJN, Aran Frank [NL/NL]; NL (UsOnly)
NEIJSSEN, Joost J. [NL/NL]; NL (UsOnly)
MEESTERS, Joyce I. [NL/NL]; NL (UsOnly)
PARREN, Paul [NL/NL]; NL (UsOnly)
SCHUURMAN, Janine [NL/NL]; NL (UsOnly)
Inventors:
DE GOEIJ, Bart; NL
VAN BERKEL, Patrick; NL
STRUMANE, Kristin; NL
LABRIJN, Aran Frank; NL
NEIJSSEN, Joost J.; NL
MEESTERS, Joyce I.; NL
PARREN, Paul; NL
SCHUURMAN, Janine; NL
Common
Representative:
GENMAB A/S; Bredgade 34 E DK-1260 Copenhagen K, DK
Priority Data:
61/552,26727.10.2011US
PA 2011 0031220.04.2011DK
PA 2011 0082227.10.2011DK
PCT/EP2011/05638820.04.2011EP
PCT/EP2011/05877227.05.2011EP
PCT/EP2011/05877927.05.2011EP
Title (EN) BISPECIFC ANTIBODIES AGAINST HER2
(FR) ANTICORPS BISPÉCIFIQUES CONTRE HER2
Abstract:
(EN) Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
(FR) La présente invention concerne des anticorps bispécifiques qui comprennent des régions de liaison d'antigène se liant à deux différents épitopes de récepteur de facteur de croissance épidermique humain 2 (HER2), et des compositions et molécules à base d'anticorps associées. La présente invention concerne en outre des compositions pharmaceutiques comprenant les anticorps et procédés de préparation et l'utilisation des anticorps.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2832387EP2699260CN103796678US20140170148JP2014517823IN8207/CHENP/2013