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1. (WO2012138453) EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/138453 International Application No.: PCT/US2012/028802
Publication Date: 11.10.2012 International Filing Date: 12.03.2012
IPC:
C12N 15/87 (2006.01) ,C12N 15/11 (2006.01) ,A61K 48/00 (2006.01) ,A61P 43/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
THE GENERAL HOSPITAL CORPORATION [US/US]; d/b/a/ Massachusetts General Hospital 55 Fruit Street Boston, MA 02114, US (AllExceptUS)
IMMUNE DISEASE INSTITUTE, INC. [US/US]; Three Blackfan Circle CLSB Third Floor Boston, MA 02115, US (AllExceptUS)
CHIEN, Kenneth, R. [US/US]; US (UsOnly)
PTASZEK, Leon, M. [US/US]; US (UsOnly)
LUI, Kathy, Oi-Lan; US (UsOnly)
ZANGI, Lior [IL/US]; US (UsOnly)
EBINA, Wataru [JP/US]; US (UsOnly)
ROSSI, Derrick J. [CA/US]; US (UsOnly)
Inventors:
CHIEN, Kenneth, R.; US
PTASZEK, Leon, M.; US
LUI, Kathy, Oi-Lan; US
ZANGI, Lior; US
EBINA, Wataru; US
ROSSI, Derrick J.; US
Agent:
RESNICK, David S.; Nixon Peabody LLP 100 Summer Street Boston, MA 02110-2131, US
Priority Data:
61/471,16603.04.2011US
61/471,58404.04.2011US
Title (EN) EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
(FR) EXPRESSION PROTÉIQUE EFFICACE IN VIVO À L'AIDE D'ARN MODIFIÉ (MOD-ARN)
Abstract:
(EN) Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
(FR) Des aspects de la présente invention concernent des ARN synthétiques, modifiés, et leur utilisation in vivo pour moduler l'expression génique. Des aspects de l'invention concernent en outre l'utilisation de ces ARN synthétiques, modifiés, dans des myocytes, des cardiomyocytes et des tumeurs.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)