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1. WO2012136133 - USE OF A-NOR-5ALPHA-ANDROSTANE COMPOUNDS FOR PREPARING ANTI-MALIGNANT TUMOR MEDICINE

Publication Number WO/2012/136133
Publication Date 11.10.2012
International Application No. PCT/CN2012/073490
International Filing Date 01.04.2012
IPC
A61K 31/568 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
568substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/568
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
568substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 上海奥奇医药科技有限公司 SHANGHAI AO QI MEDICAL TECHNOLOGY CO., LTD. [CN]/[CN] (AllExceptUS)
  • 李瑞麟 LI, Ruilin [CN]/[CN] (UsOnly)
  • 曹振全 CAO, Zhenquan [CN]/[CN] (UsOnly)
  • 谌志华 CHEN, Zhihua [CN]/[CN] (UsOnly)
  • 傅大熙 FU, Daxi [CN]/[CN] (UsOnly)
  • 陈雅君 CHEN, Yajun [CN]/[CN] (UsOnly)
Inventors
  • 李瑞麟 LI, Ruilin
  • 曹振全 CAO, Zhenquan
  • 谌志华 CHEN, Zhihua
  • 傅大熙 FU, Daxi
  • 陈雅君 CHEN, Yajun
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201110088946.408.04.2011CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) USE OF A-NOR-5ALPHA-ANDROSTANE COMPOUNDS FOR PREPARING ANTI-MALIGNANT TUMOR MEDICINE
(FR) UTILISATION DE COMPOSÉS DE A-NOR-5ALPHA-ANDROSTANE POUR PRÉPARER UN MÉDICAMENT ANTI-TUMEUR MALIGNE
(ZH) A-失碳-5α-雄甾烷化合物在制备抗恶性肿瘤药物中的应用
Abstract
(EN)
The present invention discloses the use of A-nor-5alpha-androstane compounds for preparing anti-malignant tumor medicine. In vitro experiments show that the A-nor-5alpha-Androstane Compounds have activity for inhibiting a variety of tumor cells in vitro,and growth inhibition rate averages more than 85%.In vivo experiments show that the A-nor-5alpha-androstane compounds can inhibit a variety of tumors, such as colon cancer, hepatic cancer, lung cancer, breast cancer, B16 melanoma etc. The invention also discloses the composition of anticancer drug and the method for treating cancer.
(FR)
La présente invention concerne l'utilisation de composés de A-nor-5alpha-androstane pour préparer un médicament anti-tumeur maligne. Des essais in vitro montrent que les composés de A-nor-5alpha-androstane ont une activité pour inhiber différentes cellules tumorales in vitro, et un taux d'inhibition de croissance moyen de plus de 85 %. Des essais in vivo montrent que les composés de A-nor-5alpha-androstane peuvent inhiber différentes tumeurs, telles qu'un cancer du côlon, un cancer hépatique, un cancer du poumon, un cancer du sein, un mélanome B16, etc. L'invention concerne en outre la composition de médicament anticancéreux et le procédé pour traiter un cancer.
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