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1. (WO2012135522) PROCESS FOR MANUFACTURING CONJUGATES OF IMPROVED HOMOGENEITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/135522 International Application No.: PCT/US2012/031253
Publication Date: 04.10.2012 International Filing Date: 29.03.2012
IPC:
A61K 47/48 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
IMMUNOGEN, INC. [US/US]; 830 Winter Street Waltham, MA 02451-1477, US (AllExceptUS)
JIN, Shengjin [US/US]; US (UsOnly)
Inventors:
JIN, Shengjin; US
Agent:
DISE, Rebecca, S.; Leydig, Voit & Mayer, Ltd. Two Prudential Plaza, Suite 4900 180 North Stetson Avenue Chicago, IL 60601-6731, US
Priority Data:
61/468,98129.03.2011US
61/468,99729.03.2011US (Priority Withdrawn 26.09.2013)
Title (EN) PROCESS FOR MANUFACTURING CONJUGATES OF IMPROVED HOMOGENEITY
(FR) PROCÉDÉ ET FABRICATION DE CONJUGUÉS D'HOMOGÉNÉITÉ AMÉLIORÉE
Abstract:
(EN) The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved homogeneity comprising performing the modification reaction at a lower temperature. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent at a temperature of about 15° C or less to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.
(FR) L'invention concerne des procédés de fabrication de conjugués agent de liaison cellulaire-agent cytotoxique dont l'homogénéité est améliorée, lesdits procédés comportant l'exécution de la réaction de modification à une température inférieure. Les procédés selon l'invention comportent la mise en contact d'un agent de liaison cellulaire avec un réactif de réticulation bifonctionnel à une température d'environ 15°C ou moins pour attacher de façon covalente un lieur à l'agent de liaison cellulaire et pour préparer ainsi un mélange comportant des agents de liaison cellulaire ayant des lieurs liés à ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201312639CA2831562EP2691117JP2014510757EA201391400SG193997
KR1020140019415NZ616516AU2012236403MYPI 2013701822IN7844/CHENP/2013BR112013025228