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1. WO2012131590 - AN IMPROVED PROCESS FOR PREPARATION OF FEBUXOSTAT AND ITS POLYMORPHIC CRYSTALLINE FORM C THEREOF

Publication Number WO/2012/131590
Publication Date 04.10.2012
International Application No. PCT/IB2012/051475
International Filing Date 28.03.2012
IPC
C07D 277/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
CPC
C07D 277/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applicants
  • SANDOZ AG [CH]/[IN] (AllExceptUS)
  • LUTHRA, Parven, Kumar [IN]/[IN] (UsOnly)
  • KHAN, Rashid [IN]/[IN] (UsOnly)
  • SALUNKHE, Dadasaheb [IN]/[IN] (UsOnly)
  • NASIR ALI, Shafakat, Ali [IN]/[IN] (UsOnly)
Inventors
  • LUTHRA, Parven, Kumar
  • KHAN, Rashid
  • SALUNKHE, Dadasaheb
  • NASIR ALI, Shafakat, Ali
Agents
  • MAJUMDAR, Subhatosh
Priority Data
1106/MUM/201131.03.2011IN
664/KOL/201116.05.2011IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AN IMPROVED PROCESS FOR PREPARATION OF FEBUXOSTAT AND ITS POLYMORPHIC CRYSTALLINE FORM C THEREOF
(FR) PROCÉDÉ DE PRÉPARATION AMÉLIORÉ DU FÉBUXOSTAT ET DE SA FORME CRISTALLINE POLYMORPHE C
Abstract
(EN)
The present invention relates to process of preparation of 2-(3-cyano-4- isobutyloxyphenyl)-4-methyl-5-thiazole carboxylic acid (Febuxostat). The present invention in particular relates to an efficient and easily to operate scalable process of manufacturing of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole carboxylic acid (Febuxostat) of Formula I and its crystalline polymorphic Form C.
(FR)
Cette invention concerne un procédé de préparation d'acide 2-(3-cyano-4- isobutyloxyphényl)-4-méthyl-5-thiazole carboxylique (Fébuxostat). Cette invention concerne en particulier un moyen efficace et facile de mise en œuvre d'un procédé évolutif de fabrication d'acide 2-(3-cyano-4-isobutyl- oxyphényl)-4-méthyl-5-thiazole carboxylique (Fébuxostat) de Formule I et de sa forme cristalline polymorphe C.
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