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1. (WO2012131053) METHODS OF TREATING IMMUNE DISORDERS WITH SINGLE DOMAIN ANTIBODIES AGAINST TNF-ALPHA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/131053 International Application No.: PCT/EP2012/055830
Publication Date: 04.10.2012 International Filing Date: 30.03.2012
IPC:
C07K 16/18 (2006.01) ,C07K 16/24 (2006.01) ,C07K 16/46 (2006.01) ,A61K 39/395 (2006.01) ,A61P 37/06 (2006.01) ,A61P 19/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
Applicants:
HEGEN, Martin [DE/US]; US (UsOnly)
COMER, Gail [US/US]; US (UsOnly)
SHARMA, Amarnath [US/US]; US (UsOnly)
SHIELDS, Kathy [US/US]; US (UsOnly)
ABLYNX NV [BE/BE]; Technologiepark 21 B-9052 Ghent-Zwijnaarde, BE (AllExceptUS)
Inventors:
HEGEN, Martin; US
COMER, Gail; US
SHARMA, Amarnath; US
SHIELDS, Kathy; US
Agent:
SIEGERT, Georg; HOFFMANN · EITLE Arabellastrasse 4 81925 Munich, DE
Priority Data:
61/469,38830.03.2011US
Title (EN) METHODS OF TREATING IMMUNE DISORDERS WITH SINGLE DOMAIN ANTIBODIES AGAINST TNF-ALPHA
(FR) MÉTHODES DE TRAITEMENT DE TROUBLES IMMUNITAIRES PAR DES ANTICORPS À DOMAINE UNIQUE DIRIGÉS CONTRE TNF-ALPHA
Abstract:
(EN) The invention relates to the TNFX binding molecule ozoralizumab (ATN-103), methods of using this molecule to treat immune disorders, including rheumatoid arthritis, and specific dosing regimens for the treatment of rheumatoid arthritis.
(FR) L'invention concerne une molécule de liaison à TNFX, l'ozoralizumab (ATN-103), des procédés d'utilisation de cette molécule pour traiter des troubles immunitaires, notamment la polyarthrite rhumatoïde, et des régimes posologiques spécifiques pour le traitement de la polyarthrite rhumatoïde.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)