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1. WO2012131035 - COMPOSITION COMPRISING DOCETAXEL

Publication Number WO/2012/131035
Publication Date 04.10.2012
International Application No. PCT/EP2012/055786
International Filing Date 30.03.2012
IPC
A61K 31/337 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 31/381 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/337
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • ELARA PHARMACEUTICALS GMBH [DE]/[DE] (AllExceptUS)
  • MCLAUGHLIN, Fiona [GB]/[GB] (UsOnly)
  • LEWIS, Joe [GB]/[DE] (UsOnly)
Inventors
  • MCLAUGHLIN, Fiona
  • LEWIS, Joe
Agents
  • REITSTÖTTER, KINZEBACH & PARTNER
Priority Data
PCT/EP2011/05502831.03.2011EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITION COMPRISING DOCETAXEL
(FR) COMPOSITION COMPRENANT DU DOCÉTAXEL
Abstract
(EN)
The present invention relates to a composition comprising docetaxel or a solvate thereof and a phenylsulfonamide compound of the formula I as described herein. The invention also relates to said composition for use as a medicament, especially for treating or preventing hyperproliferative diseases, such as tumor or cancer diseases or precancerosis, to the use of said composition for preparing a medicament for treating or preventing hyperproliferative diseases, such as tumor or cancer diseases or precancerosis, and to a method for treating or preventing hyperproliferative diseases, such as tumor or cancer diseases or precancerosis, by administering said composition. Formula (I), wherein R1 is selected from C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy; R2 is selected from hydrogen and C1-C3-alkyl; and R3 is selected from C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy.
(FR)
La présente invention concerne une composition comprenant du docétaxel, ou l'un de ses solvates, et un composé de phényl-sulfonamide représenté par la formule (I). L'invention concerne également ladite composition convenant comme médicament, en particulier pour le traitement ou la prévention d'affections hyperproliférantes telles que les tumeurs, les cancers, ou les états précancéreux. L'invention concerne aussi l'utilisation de ladite composition pour l'élaboration d'un médicament destiné au traitement ou à la prévention d'affections hyperproliférantes telles que les tumeurs, les cancers, ou les états précancéreux. L'invention concerne enfin un procédé permettant, par administration de ladite composition, de traiter ou de prévenir des affections hyperproliférantes telles que les tumeurs, les cancers, ou les états précancéreux. Dans la formule (I), R1 est C1-C3-alkyle, C1-C3-haloalkyle, C1-C3-alcoxy ou C1-C3-haloalcoxy; R2 est hydrogène ou C1-C3-alkyle; et R3 est C1-C3-alkyle, C1-C3-haloalkyle, C1-C3-alcoxy ou C1-C3-haloalcoxy.
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