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1. WO2012130920 - PREPARATION OF 3,5-DIOXO HEXANOATE ESTER

Publication Number WO/2012/130920
Publication Date 04.10.2012
International Application No. PCT/EP2012/055582
International Filing Date 29.03.2012
IPC
C07D 319/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
C07C 67/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
30by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
317by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
32Decarboxylation
C07C 69/716 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
716Esters of keto-carboxylic acids
CPC
C07C 67/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
03by reacting an ester group with a hydroxy group
C07C 67/05
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
04by reacting carboxylic acids or symmetrical anhydrides onto unsaturated carbon-to-carbon bonds
05with oxidation
C07C 67/297
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
28by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
297by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
C07C 67/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
30by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
317by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
32Decarboxylation
C07D 207/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 239/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
Applicants
  • LONZA LTD [CH]/[CH] (AllExceptUS)
  • JACKSON, Barry [GB]/[CH] (UsOnly)
  • NOTI, Christian [CH]/[CH] (UsOnly)
  • HU, Guixian [CN]/[CH] (UsOnly)
Inventors
  • JACKSON, Barry
  • NOTI, Christian
  • HU, Guixian
Priority Data
11002723.201.04.2011EP
11002922.007.04.2011EP
11006862.423.08.2011EP
11006872.323.08.2011EP
11007605.619.09.2011EP
11007606.419.09.2011EP
12150867.512.01.2012EP
12150868.312.01.2012EP
61/470,54801.04.2011US
61/472,82007.04.2011US
61/526,30723.08.2011US
61/526,32123.08.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION OF 3,5-DIOXO HEXANOATE ESTER
(FR) PRÉPARATION D'ESTER DE TYPE 3,5-DIOXOHEXANOATE
Abstract
(EN)
The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5- dioxohexanoatefrom Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate(BHA), Rosuvastatin and Atorvastatin.
(FR)
L'invention concerne un procédé de préparation de 6-chloro-3,5- dioxohexanoate de tert-butyle à partir d'un dérivé d'acide de Meldrum et son utilisation dans la préparation du (4R,6S)-(6-hydroxyméthyl-2,2-diméthyl-1,3-dioxan-4-yl)acétate de tert-butyle (BHA), de rosuvastatine et d'atorvastatine.
Latest bibliographic data on file with the International Bureau