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1. (WO2012129338) AZOLE COMPOUNDS AS PIM INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/129338    International Application No.:    PCT/US2012/029997
Publication Date: 27.09.2012 International Filing Date: 21.03.2012
IPC:
C07D 413/14 (2006.01), C07D 417/14 (2006.01), C07D 417/04 (2006.01), C07D 487/04 (2006.01), A61K 31/496 (2006.01), A61K 31/4439 (2006.01), A61K 31/4745 (2006.01), A61K 31/433 (2006.01), A61P 35/00 (2006.01)
Applicants: AMGEN INC. [US/US]; One Amgen Center Dr. Thousand Oaks, California 91320 (US) (For All Designated States Except US).
WANG, Hui-Ling [--/US]; (US) (For US Only).
CEE, Victor, J. [US/US]; (US) (For US Only).
HERBERICH, Bradley, J. [US/US]; (US) (For US Only).
JACKSON, Claire, L., M. [CA/US]; (US) (For US Only).
LANMAN, Brian, Alan [US/US]; (US) (For US Only).
NIXEY, Thomas [CA/US]; (US) (For US Only).
PETTUS, Liping, H. [US/US]; (US) (For US Only).
REED, Anthony, B. [US/US]; (US) (For US Only).
WU, Bin [CN/US]; (US) (For US Only).
WURZ, Ryan [CA/US]; (US) (For US Only).
TASKER, Andrew [GB/US]; (US) (For US Only)
Inventors: WANG, Hui-Ling; (US).
CEE, Victor, J.; (US).
HERBERICH, Bradley, J.; (US).
JACKSON, Claire, L., M.; (US).
LANMAN, Brian, Alan; (US).
NIXEY, Thomas; (US).
PETTUS, Liping, H.; (US).
REED, Anthony, B.; (US).
WU, Bin; (US).
WURZ, Ryan; (US).
TASKER, Andrew; (US)
Agent: BULOCK, Joseph, W.; One Amgen Center Dr. Thousand Oaks, California 93065 (US)
Priority Data:
61/466,410 22.03.2011 US
Title (EN) AZOLE COMPOUNDS AS PIM INHIBITORS
(FR) COMPOSÉS D'AZOLE UTILISÉS EN TANT QU'INHIBITEURS DES PIM
Abstract: front page image
(EN)The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
(FR)L'invention concerne des composés bicycliques des formules I et Ia, ainsi que des sels de ceux-ci. Dans certains modes de réalisation, l'invention porte sur des inhibiteurs ou des modulateurs de la fonction enzymatique ou de l'activité des protéines kinases Pim-1 et/ou Pim-2 et/ou Pim-3. Dans encore d'autres modes de réalisations, l'invention se rapporte à des compositions pharmaceutiques comprenant les composés divulgués ici, et à leur utilisation dans la prévention et le traitement d'états et de maladies liés aux kinases Pim, de préférence le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)