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1. (WO2012129084) GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/129084    International Application No.:    PCT/US2012/029417
Publication Date: 27.09.2012 International Filing Date: 16.03.2012
IPC:
A01N 43/00 (2006.01)
Applicants: GENZYME CORPORATION [--/US]; 500 Kendall Street Cambridge, MA 02142 (US) (For All Designated States Except US).
BOURQUE, Elyse [US/US]; (US) (For US Only).
CELATKA, Cassandra [US/US]; (US) (For US Only).
HIRTH, Bradford [US/US]; (US) (For US Only).
METZ, Markus [US/US]; (US) (For US Only).
ZHAO, Zhong [US/US]; (US) (For US Only).
SKERLJ, Renato [US/US]; (US) (For US Only).
XIANG, Yibin [US/US]; (US) (For US Only).
JANCISICS, Katherine [US/US]; (US) (For US Only).
MARSHALL, John [US/US]; (US) (For US Only).
CHENG, Seng [US/US]; (US) (For US Only).
SCHEULE, Ronald [US/US]; (US) (For US Only).
CABRERA-SALAZAR, Mario [US/US]; (US) (For US Only).
GOOD, Andrew [US/US]; (US) (For US Only)
Inventors: BOURQUE, Elyse; (US).
CELATKA, Cassandra; (US).
HIRTH, Bradford; (US).
METZ, Markus; (US).
ZHAO, Zhong; (US).
SKERLJ, Renato; (US).
XIANG, Yibin; (US).
JANCISICS, Katherine; (US).
MARSHALL, John; (US).
CHENG, Seng; (US).
SCHEULE, Ronald; (US).
CABRERA-SALAZAR, Mario; (US).
GOOD, Andrew; (US)
Agent: YOUNG, Aaron; Genzyme Corporation 1700 West Park Drive Westborough, MA 01581 (US)
Priority Data:
61/454,034 18.03.2011 US
61/590,711 25.01.2012 US
Title (EN) GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
(FR) INHIBITEURS DE LA GLUCOSYLCÉRAMIDE SYNTHASE
Abstract: front page image
(EN)The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
(FR)L'invention concerne des inhibiteurs de la glucosylcéramide synthase (GCS) utilisés pour traiter des maladies métaboliques, telles que des maladies du stockage lysosomal, seuls ou en association avec une enzymothérapie substitutive, et pour traiter le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)