WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2012128521) PHARMACEUTICAL COMPOSITION FOR TREATING AGING-ASSOCIATED DISEASES, CONTAINING PROGERIN EXPRESSION INHIBITOR AS ACTIVE INGREDIENT, AND SCREENING METHOD OF SAID PROGERIN EXPRESSION INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/128521 International Application No.: PCT/KR2012/001953
Publication Date: 27.09.2012 International Filing Date: 19.03.2012
IPC:
A61K 31/70 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 38/16 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: PARK, Bum-Joon[KR/KR]; KR (UsOnly)
HA, Nam-Chul[KR/KR]; KR (UsOnly)
SONG, Gyu-Yong[KR/KR]; KR (UsOnly)
LEE, Ji-Hyun[KR/KR]; KR (UsOnly)
LEE, Su-Jin[KR/KR]; KR (UsOnly)
JUNG, Youn-Sang[KR/KR]; KR (UsOnly)
PUSAN NATIONAL UNIVERSITY INDUSTRY UNIVERSITY COOPERATION FOUNDATION[KR/KR]; Pusan National University 30, Jangjeon-dong, Geumjeong-gu Pusan 609-735, KR (AllExceptUS)
THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY[KR/KR]; 220, Kung-dong Yuseong-gu Deajeon 305-764, KR (AllExceptUS)
Inventors: PARK, Bum-Joon; KR
HA, Nam-Chul; KR
SONG, Gyu-Yong; KR
LEE, Ji-Hyun; KR
LEE, Su-Jin; KR
JUNG, Youn-Sang; KR
Agent: TAEBAEK INTELLECTUAL PROPERTY LAW FIRM; #906, Kolon technovalley 60-4 Gasan-dong, Geumcheon-gu Seoul 153-770, KR
Priority Data:
10-2011-002430818.03.2011KR
10-2012-002702816.03.2012KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR TREATING AGING-ASSOCIATED DISEASES, CONTAINING PROGERIN EXPRESSION INHIBITOR AS ACTIVE INGREDIENT, AND SCREENING METHOD OF SAID PROGERIN EXPRESSION INHIBITOR
(FR) COMPOSITION PHARMACEUTIQUE DESTINÉE À TRAITER DES MALADIES ASSOCIÉES AU VIEILLISSEMENT, CONTENANT COMME PRINCIPE ACTIF UN INHIBITEUR DE L'EXPRESSION DE LA PROGÉRINE, ET PROCÉDÉ DE CRIBLAGE À LA RECHERCHE DUDIT INHIBITEUR DE L'EXPRESSION DE LA PROGÉRINE
(KO) 프로게린 발현 억제제를 유효성분으로 함유하는 노화 관련 질환 치료용 약학조성물 및 상기 프로게린 발현 억제제의 스크리닝 방법
Abstract:
(EN) The present invention relates to a pharmaceutical composition for treating aging-associated diseases, containing a progerin expression inhibitor as an active ingredient, a novel compound which inhibits the binding of progerin and lamin A, and a pharmaceutical composition for preventing or treating aging-associated diseases, containing the novel compound as an active ingredient. According to the present invention, the pharmaceutical composition inhibits the overexpression of progerin and inhibits the binding of progerin and lamin A, and thus is effective for treating or preventing diseases caused by the overexpression of progerin and the binding of progerin and lamin A, particularly, diseases caused in aged individuals such as kidney cancer, leukemia, prostate cancer, progeria and the like. In addition, it is possible to screen drugs with specificity, for example, a drug promoting the binding of pVHL and progerin or a drug inhibiting the binding of progerin and lamin A using a screening method of a drug for treating aging-associated diseases, and thus it is possible to effectively develop a drug for treating diseases caused in aged individuals such as kidney cancer, leukemia, prostate cancer, progeria and the like.
(FR) La présente invention concerne une composition pharmaceutique destinée à traiter des maladies associées à l'âge, contenant comme principe actif un inhibiteur de l'expression de la progérine, un nouveau composé qui inhibe la liaison de la progérine et de la lamine A, et une composition pharmaceutique destinée à prévenir ou à traiter des maladies associées à l'âge, contenant le nouveau composé comme principe actif. Selon la présente invention, la composition pharmaceutique inhibe la surexpression de la progérine et inhibe la liaison de la progérine et de la lamine A, et est ainsi efficace pour traiter ou prévenir des maladies causées par la surexpression de la progérine et la liaison de la progérine et de la lamine A, en particulier, des maladies présentes chez des individus âgés telles que le cancer du rein, la leucémie, le cancer de la prostate, la progérie et équivalents. De plus, il est possible de cribler des médicaments de manière spécifique, par exemple, à la recherche d'un médicament favorisant la liaison du pVHL et de la progérine ou un médicament inhibant la liaison de la progérine et de la lamine A, en utilisant un procédé de criblage à la recherche d'un médicament destiné à traiter des maladies associées au vieillissement. Il est alors possible de développer de manière efficace un médicament destiné à traiter des maladies présentes chez des individus âgés telles que le cancer du rein, la leucémie, le cancer de la prostate, la progérie et équivalents.
(KO) 본 발명은 프로게린 발현 억제제를 유효성분으로 함유하는 노화 관련 질환 치료용 약학조성물 및 프로게린 및 라민 A간의 결합을 억제하는 신규 화합물, 상기 신규 화합물을 유효성분으로 포함하는 노화 관련 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 약학조성물은 프로게린의 과발현을 억제하고 프로게린과 라민 A간의 결합을 억제하는 바, 프로게린 과발현 및 프로게린과 라민 A의 결합에 의해 야기되는 질환, 특히 신장암, 백혈병, 전립선암, 조로증 등과 같은 노화된 개체에서 야기되는 질환의 치료 또는 예방에 효과적이며, 또한 노화 관련 질환 치료제 스크리닝 방법을 이용하면 예를들어 pVHL과 프로게린 간의 결합을 촉진하는 약물 또는 프로게린 및 라민 A간의 결합을 억제하는 약물을 특이적으로 선별할 수 있어 신장암, 백혈병, 전립선암, 조로증 등과 같은 노화된 개체에서 야기되는 질환 치료제를 효과적으로 개발할 수 있다.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)