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1. (WO2012127506) SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/127506    International Application No.:    PCT/IN2012/000191
Publication Date: 27.09.2012 International Filing Date: 21.03.2012
IPC:
C07D 487/14 (2006.01), A61K 31/4375 (2006.01), A61P 25/00 (2006.01), A61P 35/00 (2006.01)
Applicants: ADVINUS THERAPEUTICS LIMITED [IN/IN]; 21 & 22, Peenya Industrial Area Phase II Bangalore 560058 (IN) (For All Designated States Except US).
BARAWKAR, Dinesh [IN/IN]; (IN) (For US Only).
BENDE, Tanushree [IN/IN]; (IN) (For US Only).
ZAHLER, Robert [US/US]; (US) (For US Only).
BANDYOPADHYAY, Anish [IN/IN]; (IN) (For US Only).
SARANGTHEM, Robindro Singh [IN/IN]; (IN) (For US Only).
DOSHI, Jignesh [IN/IN]; (IN) (For US Only).
WAMAN, Yogesh [IN/IN]; (IN) (For US Only).
JADHAV, Rushikesh [IN/IN]; (IN) (For US Only).
SINGH, Umesh Prasad [IN/IN]; (IN) (For US Only)
Inventors: BARAWKAR, Dinesh; (IN).
BENDE, Tanushree; (IN).
ZAHLER, Robert; (US).
BANDYOPADHYAY, Anish; (IN).
SARANGTHEM, Robindro Singh; (IN).
DOSHI, Jignesh; (IN).
WAMAN, Yogesh; (IN).
JADHAV, Rushikesh; (IN).
SINGH, Umesh Prasad; (IN)
Agent: VARADACHARI,, Lakshmikumaran; Lakshmikumaran & Sridharan B-6/10, Safdarjung Enclave New Delhi 110029 (IN)
Priority Data:
891/CHE/2011 22.03.2011 IN
Title (EN) SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
(FR) COMPOSÉS TRICYCLIQUES SUBSTITUÉS; COMPOSITIONS ET APPLICATIONS MÉDICINALES CORRESPONDANTES
Abstract: front page image
(EN)The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them.
(FR)La présente invention concerne des composés tricycliques substitués représentés par la formule (I) ou (Ia), leurs tautomères, des polymorphes, des stéréoisomères, des promédicaments, des solvates, des co-cristaux, des sels pharmaceutiquement acceptables, des compositions pharmaceutiquement acceptables les contenant et des méthodes permettant de traiter des affections et des maladies provoquées par l'activité de JAK. Les composés de la présente invention sont utiles dans le traitement, la prévention ou la suppression de maladies et de troubles provoqués par l'activité de JAK. De telles affections comprennent, entre autres, l'arthrite, la maladie d'Alzheimer, les thyroïdiques auto-immunes, le cancer,le diabète, la leucémie, la leucémie prolymphocytaire T, le lymphome, les syndromes myéloprolifératifs, le lupus, le myélome multiple, la sclérose en plaques, l'arthrose, la sepsie, la polyarthrite psoriasique, le cancer de la prostate, une maladie lymphocytaire T autoimmune, des maladies inflammatoires, un rejet de greffe allogénique chronique et sévère, une greffe de moelle osseuse, un accident vasculaire cérébral, l'asthme, maladie pulmonaire obstructive chronique, une allergie, une bronchite, des maladies virales, la maladie de Crohn, la sécheresse oculaire, l'uvéite, la maladie intestinale inflammatoire, le rejet d'une greffe d'organe, le psoriasis, et la colite ulcéreuse.. La présente invention concerne également un procédé permettant de préparer ces composés ainsi que des compositions pharmaceutiques les contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)