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1. (WO2012127466) 5-AMINOLEVULINIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/127466 International Application No.: PCT/IL2012/000127
Publication Date: 27.09.2012 International Filing Date: 22.03.2012
IPC:
A61K 31/221 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
221
with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
Applicants: REPHAELI, Ada[IL/IL]; IL (UsOnly)
TARASENKO, Nataly[IL/IL]; IL (UsOnly)
MALIK, Zvi[IL/IL]; IL (UsOnly)
NUDELMAN, Abraham[IL/IL]; IL (UsOnly)
BERKOVITCH-LURIA, Gili[IL/IL]; IL (UsOnly)
DORON, Dvir[IL/IL]; IL (UsOnly)
BAR ILAN UNIVERSITY[IL/IL]; 52900 Ramat Gan, IL (AllExceptUS)
RAMOT AT TEL AVIV UNIVERSITY LTD.[IL/IL]; P.O. Box 39296 61392 Tel Aviv, IL (AllExceptUS)
Inventors: REPHAELI, Ada; IL
TARASENKO, Nataly; IL
MALIK, Zvi; IL
NUDELMAN, Abraham; IL
BERKOVITCH-LURIA, Gili; IL
DORON, Dvir; IL
Agent: WEBB & CO; P.O. Box 2189 76121 Rehovot, IL
Priority Data:
61/466,98724.03.2011US
61/514,05302.08.2011US
Title (EN) 5-AMINOLEVULINIC ACID DERIVATIVES, METHODS FOR THEIR PREPARATION AND USES THEREOF
(FR) DÉRIVÉS D'ACIDE 5-AMINOLÉVULINIQUE, PROCÉDÉS POUR LEUR PRÉPARATION ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides drug conjugates comprising 5-aminolevulinic acid (ALA), an aldehyde and a carboxylic acid that may function as a histone deacetylase inhibitor (HDACI). These conjugates may serve as co-drugs which release a plurality of active species in vivo. The novel drug conjugates may be used, for the treatment or prevention of cancer in PDT-dependent and/or PDT-independent (nonPDT) treatments, as well as for cosmetic uses. In addition the present invention provides novel uses for both the novel and known compounds. According to some embodiments, the present invention provides drug conjugates (co-drugs) comprising (i) ALA, (ii) an aldehyde and (iii) a carboxylic acid that may function as a histone deacetylase inhibitor (HDACO for the treatment of anemia and/or for the induction of erythropoiesis.
(FR) L'invention concerne des conjugués comprenant de l'acide 5-aminolévulinique (5-ALA), un aldéhyde et un acide carboxylique qui peut fonctionner comme un inhibiteur d'histone désacétylase (HDACI). Ces conjugués peuvent servir de co-drogues qui libèrent une pluralité d'espèces actives in vivo. Ces nouveaux conjugués médicaments peuvent être utilisés pour le traitement ou la prévention du cancer dans des traitements dépendant du TPD et/ou indépendant du TPD (nonTPD), ainsi qu'à des fins cosmétiques. La présente invention concerne de nouvelles utilisations à la fois pour les composés nouveaux et connus. Selon certains modes de réalisation, la présente invention concerne des conjugués médicaments (co-drogues) comprenant (i) ALA, (ii) un aldéhyde et (iii) un acide carboxylique pouvant fonctionner comme un inhibiteur d'histone déacétylase (HDAC) pour le traitement d'anémie et/ou pour l'induction de l'érythropoïèse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)