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1. (WO2012127037) A COMPOSITION COMPRISING LIPID NANOPARTICLES AND A CORTICOSTEROID OR VITAMIN D DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/127037    International Application No.:    PCT/EP2012/055222
Publication Date: 27.09.2012 International Filing Date: 23.03.2012
IPC:
A61K 9/51 (2006.01), A61K 9/06 (2006.01), A61K 31/573 (2006.01), A61K 31/593 (2006.01), A61P 17/00 (2006.01), A61P 3/02 (2006.01), A61K 9/00 (2006.01)
Applicants: LEO Pharma A/S [DK/DK]; Industriparken 55 DK-2750 Ballerup (DK) (For All Designated States Except US).
JENSEN, Louise Bastholm [DK/DK]; (DK) (For US Only).
PETERSSON, Karsten [DK/DK]; (DK) (For US Only)
Inventors: JENSEN, Louise Bastholm; (DK).
PETERSSON, Karsten; (DK)
Priority Data:
61/467,192 24.03.2011 US
Title (EN) A COMPOSITION COMPRISING LIPID NANOPARTICLES AND A CORTICOSTEROID OR VITAMIN D DERIVATIVE
(FR) COMPOSITION COMPRENANT DES NANOPARTICULES LIPIDIQUES ET UN CORTICOSTÉROÏDE OU UN DÉRIVÉ DE VITAMINE D
Abstract: front page image
(EN)A pharmaceutical composition comprises, as a therapeutically active ingredient, a corticosteroid and/or vitamin D derivative incorporated as a solid solution or dispersion in lipid nanopartides, said lipid nanopartides being solid at ambient temperature and comprising a first lipid with a melting point above body temperature, the first lipid being a wax selected from the group consisting of esters of C12-24 alcohols and C12-24 fatty acids, glyceryl mono-, di- or triesters of C12-24 fatty acids, C12-24 fatty alcohols, and cholesterol, optionally a second lipid which is an oil at ambient temperature and miscible with the first lipid, and a pharmaceutically acceptable surfactant.
(FR)La composition pharmaceutique ci-décrite comprend, à titre de principe thérapeutiquement actif, un corticostéroïde et/ou un dérivé de vitamine D incorporé sous forme de solution ou de suspension solide dans des nanoparticules lipidiques, lesdites particules nanolipidiques étant solides à température ambiante et comprenant un premier lipide ayant un point de fusion supérieur à la température corporelle, ledit premier lipide étant une cire choisie dans le groupe constitué par les esters d'alcools C12-24 et d'acides gras C12-24, les mono-, di- ou triesters glycéryliques d'acides gras C12-24, d'alcools gras C12-24, et du cholestérol, éventuellement un second lipide qui est une huile à température ambiante et miscible au premier lipide, et un tensioactif pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)