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1. (WO2012126940) IMMUNE SUPPRESSOR AND ITS USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/126940 International Application No.: PCT/EP2012/054985
Publication Date: 27.09.2012 International Filing Date: 21.03.2012
IPC:
A61K 38/16 (2006.01) ,G01N 33/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants: KAY-FEDOROV, Penelope[GB/DE]; DE (UsOnly)
MESSERLE, Martin[DE/DE]; DE (UsOnly)
SCHULZ, Thomas, F.[DE/DE]; DE (UsOnly)
STEINBRÜCK, Lars[DE/DE]; DE (UsOnly)
GABAEV, Ildar[RU/DE]; DE (UsOnly)
MEDIZINISCHE HOCHSCHULE HANNOVER[DE/DE]; Carl-Neuberg-Strasse 1 30625 Hannover, DE (AllExceptUS)
Inventors: KAY-FEDOROV, Penelope; DE
MESSERLE, Martin; DE
SCHULZ, Thomas, F.; DE
STEINBRÜCK, Lars; DE
GABAEV, Ildar; DE
Agent: KRÖNCKE, Rolf; Gramm, Lins & Partner GbR Freundallee 13a 30173 Hannover, DE
Priority Data:
11159203.622.03.2011EP
Title (EN) IMMUNE SUPPRESSOR AND ITS USE
(FR) IMMUNOSUPPRESSEUR ET SON UTILISATION
Abstract:
(EN) The present invention relates to a new binder molecule useful e.g. as an immune suppressor. In particular, it has been recognized that the UL11 protein of human the cytomegalovirus, binds to the CD45 molecule, potentially altering the immune system of an individual. In addition, the present invention relates to binder molecules, in particular, fusion molecules containing the CD45 binding domain of the UL11 protein in combination with a second molecule of interest for delivery of said molecule to cells expressing the CD45 molecule. Moreover, the present invention relates to pharmaceutical compositions comprising the UL11 protein of human cytomegalovirus, or derivatives or homologs thereof, or a nucleic acid sequence encoding the same.
(FR) La présente invention concerne une nouvelle molécule de liaison utile par exemple, en tant qu'immunosuppresseur. Il a notamment été admis que la protéine UL11 du cytomégalovirus humain se liait à la molécule CD45, modifiant potentiellement le système immunitaire d'un individu. La présente invention concerne en outre des molécules de liaison, en particulier des molécules de fusion contenant le domaine de liaison à CD45 de la protéine UL11 en combinaison avec une seconde molécule d'intérêt pour l'administration de ladite molécule à des cellules exprimant la molécule CD45. La présente invention concerne également des compositions pharmaceutiques comprenant la protéine UL11 du cytomégalovirus humain, ou des dérivés ou homologues de ladite protéine, ou une séquence d'acide nucléique codant pour ladite protéine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)