EP2012054849 BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE

1. (WO2012126901) BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE

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Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2012/126901		International Application No.:		PCT/EP2012/054849
Publication Date:		27.09.2012		International Filing Date:		20.03.2012

IPC:

C07D 498/04 (2006.01), C07D 498/14 (2006.01), C07D 519/00 (2006.01), A61K 31/553 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01), A61P 19/00 (2006.01), A61P 31/12 (2006.01), A61P 5/00 (2006.01), A61P 3/00 (2006.01), A61P 25/00 (2006.01)

Applicants:

F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
ELLIOTT, Richard [GB/GB]; (GB) (For US Only).
GANCIA, Emanuela [GB/GB]; (GB) (For US Only).
HEALD, Robert [GB/GB]; (GB) (For US Only).
HEFFRON, Timothy [US/US]; (US) (For US Only).
SAFINA, Brian [US/US]; (US) (For US Only).
SEWARD, Eileen, M. [IE/GB]; (GB) (For US Only).
STABEN, Steven [US/US]; (US) (For US Only).
SUTHERLIN, Daniel, P. [US/US]; (US) (For US Only).
WASZKOWYCZ, Bohdan [GB/GB]; (GB) (For US Only).
WEI, BinQing [CN/US]; (US) (For US Only)

Inventors:

ELLIOTT, Richard; (GB).
GANCIA, Emanuela; (GB).
HEALD, Robert; (GB).
HEFFRON, Timothy; (US).
SAFINA, Brian; (US).
SEWARD, Eileen, M.; (GB).
STABEN, Steven; (US).
SUTHERLIN, Daniel, P.; (US).
WASZKOWYCZ, Bohdan; (GB).
WEI, BinQing; (US)

Agent:

SAUER, Frank; Grenzacherstrasse 124 CH-4070 Basel (CH)

Priority Data:

61/454,672

21.03.2011

Title

(EN) BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE
(FR) COMPOSÉS DE BENZOXAZÉPINE SÉLECTIFS POUR PI3K P110 DELTA ET LEURS MÉTHODES D'UTILISATION

Abstract:

(EN)Benzoxazepin Formula (I) compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
(FR)La présente invention concerne des composés de benzoxazépine de formule (I), y compris leurs stéréo-isomères, leurs isomères géométriques, leurs tautomères, leurs métabolites et des sels pharmaceutiquement acceptables de ceux-ci, qui peuvent être utilisés en vue de l'inhibition de l'isoforme delta de PI3K et du traitement d'affections à médiation par les lipides-kinases comme l'inflammation, les affections immunologiques et le cancer. L'invention concerne des méthodes d'utilisation des composés de formule (I) en vue du diagnostic in vitro, in situ et in vivo, de la prévention ou du traitement, dans des cellules de mammifère, desdites affections ou de pathologies associées.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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