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Machine translation
1. (WO2012126791) 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/126791    International Application No.:    PCT/EP2012/054510
Publication Date: 27.09.2012 International Filing Date: 15.03.2012
IPC:
C07D 267/10 (2006.01), C07D 413/12 (2006.01), A61K 31/553 (2006.01), A61P 25/28 (2006.01), A61P 3/10 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
SIENA BIOTECH S.P.A [IT/IT]; Strada del Petriccio e Belriguardo 35 I-53100 Siena (IT) (For All Designated States Except US).
GABELLIERI, Emanuele [IT/IT]; (IT) (For US Only).
GUBA, Wolfgang [DE/DE]; (DE) (For US Only).
HILPERT, Hans [CH/CH]; (CH) (For US Only).
MAUSER, Harald [DE/CH]; (CH) (For US Only).
MAYWEG, Alexander V. [DE/CN]; (CN) (For US Only).
ROGERS-EVANS, Mark [GB/CH]; (CH) (For US Only).
ROMBACH, Didier [FR/FR]; (FR) (For US Only).
THOMAS, Andrew [GB/CH]; (CH) (For US Only).
WOLTERING, Thomas [DE/DE]; (DE) (For US Only).
WOSTL, Wolfgang [DE/DE]; (DE) (For US Only)
Inventors: GABELLIERI, Emanuele; (IT).
GUBA, Wolfgang; (DE).
HILPERT, Hans; (CH).
MAUSER, Harald; (CH).
MAYWEG, Alexander V.; (CN).
ROGERS-EVANS, Mark; (CH).
ROMBACH, Didier; (FR).
THOMAS, Andrew; (CH).
WOLTERING, Thomas; (DE).
WOSTL, Wolfgang; (DE)
Agent: MUELLER-AFRAZ, Simona; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
11158781.2 18.03.2011 EP
Title (EN) 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
(FR) 1,4-OXAZÉPINES UTILISABLES EN TANT QU'INHIBITEURS DE BACE1 ET/OU BACE2
Abstract: front page image
(EN)The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
(FR)La présente invention concerne des 1,4-oxazépines de formule 1 ayant une activité inhibitrice sur BACE1 et/ou BACE2, leur fabrication, des compositions pharmaceutiques en contenant et leur utilisation en tant que substances thérapeutiquement actives. Les composés actifs de la présente invention peuvent être utilisés dans le cadre d'un traitement thérapeutique et/ou prophylactique, par exemple de la maladie d'Alzheimer et du diabète de type 2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)