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1. (WO2012126278) TERBINAFINE REVERSE THERMO-SENSITIVE REVERSIBLE AQUAGEL COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/126278 International Application No.: PCT/CN2012/000349
Publication Date: 27.09.2012 International Filing Date: 20.03.2012
IPC:
A61K 31/137 (2006.01) ,A61K 9/00 (2006.01) ,A61K 31/4545 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
137
Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
4545
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
Applicants: LU, Shaoxiang[US/CN]; CN (UsOnly)
LU, Meibo[US/CN]; CN (UsOnly)
LIU, Letian[US/CN]; CN (UsOnly)
BRODA TECHNOLOGIES CO., LTD.[CN/CN]; LU, Shaoxiang Room 505, 781 Cailun Road Zhangjiang High Tech Park Shanghai 201203, CN (AllExceptUS)
Inventors: LU, Shaoxiang; CN
LU, Meibo; CN
LIU, Letian; CN
Agent: SHANGHAI WATSON & BAND LAW OFFICES; 26th/F Wenxin United Press Tower 755 Weihai Road Shanghai 200041, CN
Priority Data:
PCT/CN2011/00046221.03.2011CN
Title (EN) TERBINAFINE REVERSE THERMO-SENSITIVE REVERSIBLE AQUAGEL COMPOSITION
(FR) COMPOSITION D'AQUAGEL RÉVERSIBLE RÉCIPROQUEMENT THERMOSENSIBLE DE TERBINAFINE
(ZH) 特比萘芬逆向温敏可逆水凝胶组合物
Abstract:
(EN) The present invention provides a more effective reverse thermo-sensitive reversible aquagel composition comprising terbinafine or the acid addition salt thereof for treating a fungal infection of skin or skin appendages, and a method of using the reverse thermo-sensitive reversible aquagel composition; the composition comprises:(a) a water soluble block copolymer comprising at least two polyethylene oxide blocks and at least one polypropylene oxide block; and (b) at least one associated gel adjuvant, which has a water solubility less than 0.5 g/l00 ml at 20°C, preferably less than 0.3 g/100 ml, and which can form a water-soluble intermolecular complex with the abovementoned water soluble block copolymer; and (c) an effective dose of terbinafine or the acid addition salt thereof. The aquagel composition of the present invention is effective in treating a fungal infection of skin or skin appendages.
(FR) La présente invention concerne une composition d'aquagel réversible réciproquement thermosensible d'efficacité supérieure comprenant de la terbinafine ou son sel d'addition acide dans le traitement d'une infection fongique de la peau ou des appendices de la peau, ainsi qu'une méthode d'utilisation de la composition d'aquagel réversible réciproquement thermosensible ; la composition comprend (a) : un copolymère bloc hydrosoluble comprenant au moins deux blocs polyoxyde d'éthylène et au moins un bloc polyoxyde de propylène ; et (b) au moins un adjuvant en gel associé, de solubilité dans l'eau inférieure à 0,5 g/100 mL à 20 °C, préférentiellement inférieure à 0,3 g/100 mL, et pouvant former un complexe intermoléculaire hydrosoluble avec le copolymère bloc hydrosoluble susmentionné ; et (c) une dose active de terbinafine ou de son sel d'addition acide. La composition d'aquagel selon la présente invention permet le traitement efficace d'une infection fongique de la peau ou des appendices de la peau.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)