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1. (WO2012125926) TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/125926    International Application No.:    PCT/US2012/029446
Publication Date: 20.09.2012 International Filing Date: 16.03.2012
IPC:
C07F 9/28 (2006.01), C07D 291/00 (2006.01), C07D 498/00 (2006.01), A01N 43/50 (2006.01)
Applicants: MERCK SHARP & DOHME CORP [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
COBURN, Craig, A. [US/US]; (US) (NZ, US only).
ROSENBLUM, Stuart, B. [US/US]; (US) (NZ, US only).
KOZLOWSKI, Joseph, A. [US/US]; (US) (NZ, US only).
SOLL, Richard [US/CN]; (CN) (NZ, US only).
WU, Hao [CN/CN]; (CN) (NZ, US only).
HU, Bin [CN/CN]; (CN) (NZ, US only).
ZHONG, Bin [CN/CN]; (CN) (NZ, US only).
WANG, Dahai [CN/CN]; (CN) (NZ, US only).
SHEN, Changmao [CN/CN]; (CN) (NZ, US only).
SUN, Fei [CN/CN]; (CN) (NZ, US only)
Inventors: COBURN, Craig, A.; (US).
ROSENBLUM, Stuart, B.; (US).
KOZLOWSKI, Joseph, A.; (US).
SOLL, Richard; (CN).
WU, Hao; (CN).
HU, Bin; (CN).
ZHONG, Bin; (CN).
WANG, Dahai; (CN).
SHEN, Changmao; (CN).
SUN, Fei; (CN)
Common
Representative:
MERCK SHARP & DOHME CORP; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
PCT/CN2011/071897 17.03.2011 CN
Title (EN) TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
(FR) DÉRIVÉS TÉTRACYCLIQUES DE XANTHÈNE ET LEURS MÉTHODES D'UTILISATION EN VUE DU TRAITEMENT DE MALADIES VIRALES
Abstract: front page image
(EN)The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.
(FR)La présente invention concerne des dérivés tétracycliques inédits de xanthène de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, formule (I) dans laquelle A, Y1, Y2, Z, Ra, Rb, R1a, R1b et R2 sont tels que définis ici. La présente invention concerne également des compositions contenant au moins un dérivé tétracyclique de xanthène et des méthodes d'utilisation desdits dérivés tétracycliques de xanthène en vue du traitement ou de la prévention de l'infection par le VHC chez un patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)