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1. (WO2012125884) DERIVATIVES OF CELECOXIB, USE THEREOF AND PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/125884 International Application No.: PCT/US2012/029328
Publication Date: 20.09.2012 International Filing Date: 16.03.2012
Chapter 2 Demand Filed: 15.10.2012
IPC:
A61K 31/415 (2006.01) ,C07D 231/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
12
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applicants: PIAZZA, Gary, A.[US/US]; US (UsOnly)
ABADI, Ashraf, H.[EG/EG]; EG (UsOnly)
SOUTHERN RESEARCH INSTITUTE[US/US]; Office Of Commercialization and Intellectual Property 2000 9th Avenue South P.O. Box 55305 Birmingham, AL 35205-5305, US (AllExceptUS)
GERMAN UNIVERSITY IN CAIRO[EG/EG]; Faculty Of Pharmacy and Biotechnology New Cairo City, Main Entrance Al-tagamoa Al-khames Cairo, 11835, EG (AllExceptUS)
Inventors: PIAZZA, Gary, A.; US
ABADI, Ashraf, H.; EG
Agent: AMERNICK, Burton, A.; Connolly Bove Lodge & Hutz LLP 1875 Eye Street, NW Suite 1100 Washington, DC 20006, US
Priority Data:
61/453,79517.03.2011US
Title (EN) DERIVATIVES OF CELECOXIB, USE THEREOF AND PREPARATION THEREOF
(FR) DÉRIVÉS DE CÉLÉCOXIB, LEUR UTILISATION ET LEUR PRÉPARATION
Abstract:
(EN) Derivatives of celecoxib that lack cyclooxygenase inhibitory activity but have improved PDE5 inhibitory activity are provided along with pharmaceutical compositions containing them for the treatment or prevention of cancer. Such compounds are expected to have reduced toxicity compared with celecoxib and other cyclooxygenase inhibitors, and greater efficacy compared with conventional PDE5 inhibitors. Derivatives of celecoxib are also suitable for treating chronic inflammatory conditions, erectile dysfunction, pulmonary hypertension, congestive heart failure, and enhancement of cognitive function.
(FR) La présente invention concerne des dérivés de célécoxib sans activité inhibitrice sur la cyclooxygénase, mais possèdant une activité inhibitrice améliorée sur PDE5, ainsi que des compositions pharmaceutiques les contenant pour le traitement ou la prévention du cancer. Lesdits composés sont censés avoir une toxicité réduite comparée à celle du célécoxib et d'autres inhibiteurs de cyclooxygénase, et une meilleure efficacité comparée à celle des inhibiteurs classiques de PDE5. Les dérivés de célécoxib sont également appropriés pour le traitement d'états inflammatoires chroniques, du dysfonctionnement érectile, de l'hypertension pulmonaire, de l'insuffisance cardiaque congestive, et pour l'amélioration de la fonction cognitive.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)