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Machine translation
1. (WO2012125787) METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFβ AND RUNX1 PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/125787    International Application No.:    PCT/US2012/029169
Publication Date: 20.09.2012 International Filing Date: 15.03.2012
IPC:
A61K 31/55 (2006.01), A61K 31/12 (2006.01), A61P 35/02 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC [US/US]; National Institutes Of Health Office Of Technology Transfer 6011 Executive Blvd., Suite 325 MSC 7660 Bethesda, MD 20892-7660 (US) (For All Designated States Except US).
LIU, Pu [US/US]; (US) (For US Only).
ZHENG, Wei [US/US]; (US) (For US Only).
MARUGAN, Juan, J. [US/US]; (US) (For US Only).
SOUTHALL, Noel, T. [US/US]; (US) (For US Only).
CUNNINGHAM, Lea [US/US]; (US) (For US Only)
Inventors: LIU, Pu; (US).
ZHENG, Wei; (US).
MARUGAN, Juan, J.; (US).
SOUTHALL, Noel, T.; (US).
CUNNINGHAM, Lea; (US)
Agent: RUPERT, Wayne, W.; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204 (US)
Priority Data:
61/453,863 17.03.2011 US
Title (EN) METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFβ AND RUNX1 PROTEINS
(FR) MÉTHODES DE TRAITEMENT DE LA LEUCÉMIE ET DE TROUBLES À MÉDIATION PAR LES PROTÉINES CBFΒ ET RUNX1
Abstract: front page image
(EN)A method for treating core binding factor (CBF) leukemia in a subject, comprising administering to a subject having CBF leukemia a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, that inhibits CBFβ and RUNX1 binding in the subject, thereby treating the CBF leukemia.
(FR)L'invention concerne une méthode de traitement d'une leucémie à facteur de liaison nucléaire (CBF) chez un sujet, ladite méthode comportant l'administration, à un sujet présentant une leucémie à CBF, d'une quantité thérapeutiquement efficace d'un composé, ou d'un sel ou ester de qualité pharmaceutique de celui-ci, qui inhibe la liaison à CBFβ et à RUNX1 chez le sujet, traitant ainsi la leucémie à CBF.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)