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1. (WO2012125667) TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/125667 International Application No.: PCT/US2012/028977
Publication Date: 20.09.2012 International Filing Date: 14.03.2012
IPC:
C07D 249/00 (2006.01)
Applicants: GREEN, Ahren[US/US]; US (NZ, US)
LI, Yiwei[CA/US]; US (NZ, US)
STACHEL, Shawn[US/US]; US (NZ, US)
MERCK SHARP & DOHME CORP.[US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US (AllExceptUS)
Inventors: GREEN, Ahren; US
LI, Yiwei; US
STACHEL, Shawn; US
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
61/453,60217.03.2011US
Title (EN) TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
(FR) INHIBITEURS DE KINASE TRKA, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
Abstract: front page image
(EN) The present invention is directed to pyridotriazole and benztriazole compounds of formula (I) (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
(FR) La présente invention concerne des composés pyridotriazoles et benzatriazoles, de la formule (I), qui sont des inhibiteurs de protéines kinases de la famille des kinases apparentées à la tropomyosine (Trk), et, par conséquent, qui sont utiles dans le traitement de la douleur, de l'inflammation, du cancer, de la resténose, de l'athérosclérose, du psoriasis, d'une thrombose, d'une maladie, d'un trouble, d'une lésion ou d'un dysfonctionnement associé à la myélinisation ou à la démyélinisation ou d'une maladie ou d'un trouble associé à des activités anormales du récepteur TrkA du facteur de croissance nerveux (NGF).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)